Results 101 to 110 of about 1,053,112 (188)

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

New twist on the regulation of NKG2D ligand expression [PDF]

Journal of Experimental Medicine, 2009
The NK cell–activating receptor NKG2D plays a prominent role in antitumor immune responses. Expression of the multiple NKG2D ligands must be tightly controlled to guarantee that NK cells attack tumors but not healthy cells. New data reveal a novel mechanism of posttranslational regulation of the mouse NKG2D ligand MULT1, in which MULT1 is ubiquitinated
openaire   +3 more sources

NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons

Journal of Neuroinflammation
Nociceptors are primary afferent neurons that sense noxious stimuli. They can be activated by tissue injury as well as the accompanying local immune response.
Shuaiwei Wang, Allison M. Barry, Yoon Kyung Lee, Naomi Young, Sang Wook Shim, Xinying Wang, Hyeongcheol Kim, Laura Stirling-Barros, Rafael González-Cano, Michael Costigan, Georgios Baskozos, Simon Rinaldi, David LH Bennett, Seog Bae Oh, Alexander J. Davies   +14 more
doaj   +1 more source

Potential therapeutic strategy for gastric cancer peritoneal metastasis by NKG2D ligands-specific T cells

OncoTargets and Therapy, 2015
Purpose Despite advancements in its treatment, gastric cancer continues to be one of the leading causes of cancer deaths worldwide. Adoptive transfer of chimeric antigen receptor-modified T cells is a promising antitumor therapy for many cancers.
Xianqiang Liu, Meili Sun, Shui Yu, Kai Liu, Xirui Li, Huan Shi   +5 more
semanticscholar   +1 more source

NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand

iScience
Summary: Mesenchymal stem cells (MSCs) hold potential in cancer therapy; however, insufficient tumor homing ability and heterogeneity limit their therapeutic benefits.
Shuqing Tang, Yusang Zhang, Peiyun Wang, Qiyu Tang, Yating Liu, Fan Lu, Mengting Han, Miaojin Zhou, Qian Hu, Mai Feng, Desheng Liang   +10 more
doaj   +1 more source

Cytokine-induced killer cells efficiently kill stem-like cancer cells of nasopharyngeal carcinoma via the NKG2D-ligands recognition

OncoTarget, 2015
Cancer stem cells (CSCs) are considered to be the root cause for cancer treatment failure. Thus, there remains an urgent need for more potent and safer therapies against CSCs for curing cancer.
Fang Wei, Xiaoxiang Rong, Raoying Xie, Li-Ting Jia, Huiyan Wang, Yujuan Qin, Lin Chen, Hong-fen Shen, Xiao-Lin Lin, Jie Yang, Sheng Yang, WeiChao Hao, Yan Chen, Shengjun Xiao, Hui-Rong Zhou, Tao-yan Lin, Yusheng Chen, Yan Sun, K. Yao, Dong Xiao   +19 more
semanticscholar   +1 more source

A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression

eLife, 2016
Natural Killer (NK) cells are essential for control of viral infection and cancer. NK cells express NKG2D, an activating receptor that directly recognizes NKG2D ligands.
Trever T Greene, Maria Tokuyama, Giselle M Knudsen, Michele Kunz, James Lin, Alexander L Greninger, Victor R DeFilippis, Joseph L DeRisi, David H Raulet, Laurent Coscoy   +9 more
doaj   +1 more source

Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages

eLife, 2018
NKG2D is an important immunoreceptor expressed on the surface of NK cells and some T cells. NKG2D recognizes a set of ligands typically expressed on infected or transformed cells, but recent studies have also documented NKG2D ligands on subsets of host ...
Thornton W Thompson, Benjamin T Jackson, P Jonathan Li, Jiaxi Wang, Alexander Byungsuk Kim, Kristen Ting Hui Huang, Lily Zhang, David H Raulet   +7 more
doaj   +1 more source

Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation. [PDF]

Blood Adv, 2023
Petersdorf EW, McKallor C, Malkki M, He M, Spellman SR, Hsu KC, Strong RK, Gooley T, Stevenson P.   +8 more
europepmc   +1 more source

Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition

Oncoimmunology, 2015
There is an urgent need for more potent and safer approaches to eradicate cancer stem cells (CSCs) for curing cancer. In this study, we investigate cancer-killing activity (CKA) of cytokine-induced killer (CIK) cells against CSCs of hepatocellular ...
Xiaoxiang Rong, Fang Wei, Xiao-Lin Lin, Yu-Juan Qin, Lin Chen, Huiyan Wang, Hong-fen Shen, Li-Ting Jia, Raoying Xie, Tao-yan Lin, WeiChao Hao, Jie Yang, Sheng Yang, Yushuang Cheng, Wenhua Huang, Ai-min Li, Yan Sun, Rong-cheng Luo, D. Xiao   +18 more
semanticscholar   +1 more source