Results 101 to 110 of about 381,426 (191)

New twist on the regulation of NKG2D ligand expression [PDF]

Journal of Experimental Medicine, 2009
The NK cell–activating receptor NKG2D plays a prominent role in antitumor immune responses. Expression of the multiple NKG2D ligands must be tightly controlled to guarantee that NK cells attack tumors but not healthy cells. New data reveal a novel mechanism of posttranslational regulation of the mouse NKG2D ligand MULT1, in which MULT1 is ubiquitinated
openaire   +3 more sources

Differential Mechanisms of Shedding of the Glycosylphosphatidylinositol (GPI)-anchored NKG2D Ligands

, 2010
Acknowledgments We thank R. Apps for the ULBP constructs; N. Miller for assistance with cell sorting and F. Colucci and his group, M. Field, J. Kaufman, A. Kelly, S. Powis, P. Roda-Navarro and J.
Skepper, Jeremy, Boutet, Philippe, Ashiru, Omodele, Fernández Messina, Lola María, Agüera-González, Sonia, Valés-Gómez, Mar, Reyburn, Hugh   +6 more
core   +1 more source

Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases

, 2017
NKG2D-mediated immune surveillance is crucial for inhibiting tumor growth and metastases. Malignant tumor cells often downregulate NKG2D ligands to escape from immune surveillance.
Eugenie S. Kleinerman, Liangfang Zhang, Shulin Li, Xueqing Xia, Mien-Chie Hung, Chantale Bernatchez, Jiemiao Hu, Patrick Hwu   +7 more
core   +1 more source

Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma

, 2013
Malignant cells constitutively express Natural killer group 2, member D (NKG2D) or DNAX Accessory Molecule-1 (DNAM-1) ligands, yet they are often unable to trigger a robust cytotoxic cell response. It may be therapeutically useful to implement strategies
SORIANI, Alessandra, CIPPITELLI, Marco, RICCI, BIANCAMARIA, Maria Luisa Iannitto, Iannitto, Maria Luisa, FIONDA, Cinzia, SANTONI, Angela   +6 more
core   +1 more source

NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand

iScience
Summary: Mesenchymal stem cells (MSCs) hold potential in cancer therapy; however, insufficient tumor homing ability and heterogeneity limit their therapeutic benefits.
Shuqing Tang, Yusang Zhang, Peiyun Wang, Qiyu Tang, Yating Liu, Fan Lu, Mengting Han, Miaojin Zhou, Qian Hu, Mai Feng, Desheng Liang   +10 more
doaj   +1 more source

A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression

eLife, 2016
Natural Killer (NK) cells are essential for control of viral infection and cancer. NK cells express NKG2D, an activating receptor that directly recognizes NKG2D ligands.
Trever T Greene, Maria Tokuyama, Giselle M Knudsen, Michele Kunz, James Lin, Alexander L Greninger, Victor R DeFilippis, Joseph L DeRisi, David H Raulet, Laurent Coscoy   +9 more
doaj   +1 more source

Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection [PDF]

, 2017
NK cells play a critical role in host defense against viruses. In this study, we investigated the role of NKG2D in the expansion of NK cells after mouse CMV (MCMV) infection.
Jenuš, Tina, Tsukasa Nabekura, Kouta Niizuma, Tihana Trsan, Nabekura, Tsukasa, Gotthardt, Dagmar, Stipan Jonjic, Dagmar Gotthardt, Lanier, Lewis L., Jonjić, Stipan, Tina Jenus, Lanier, Lewis L, Niizuma, Kouta, Tršan, Tihana, Lewis L. Lanier   +14 more
core   +1 more source

Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages

eLife, 2018
NKG2D is an important immunoreceptor expressed on the surface of NK cells and some T cells. NKG2D recognizes a set of ligands typically expressed on infected or transformed cells, but recent studies have also documented NKG2D ligands on subsets of host ...
Thornton W Thompson, Benjamin T Jackson, P Jonathan Li, Jiaxi Wang, Alexander Byungsuk Kim, Kristen Ting Hui Huang, Lily Zhang, David H Raulet   +7 more
doaj   +1 more source

Innate immune recognition of double-stranded RNA triggers increased expression of NKG2D ligands after virus infection [PDF]

, 2017
Self/non-self-discrimination by the innate immune system relies on germline-encoded, non-rearranging receptors expressed by innate immune cells recognizing conserved pathogen-associated molecular patterns.
Esteso, Gloria, Gloria Esteso, Susana Guerra, Valés Gómez, Mar, Hugh T. Reyburn, Guerra García, María Susana, Reyburn, Hugh T., Mar Valés-Gómez, Guerra, Susana, Reyburn, Hugh T, Valés-Gómez, Mar   +10 more
core   +1 more source

Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation. [PDF]

Blood Adv, 2023
Petersdorf EW, McKallor C, Malkki M, He M, Spellman SR, Hsu KC, Strong RK, Gooley T, Stevenson P.   +8 more
europepmc   +1 more source