Activation of immune evasion machinery is a part of the process of malignant transformation of human cells [PDF]
, 2023 Malignant transformation of human cells is associated with their re-programming which results in uncontrolled proliferation and in the same time biochemical activation of immunosuppressive pathways which form cancer immune evasion machinery.
Sumbayev, Vadim V. +21 more
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Zika Virus Pathogenesis: A Battle for Immune Evasion
, 2021 Zika virus (ZIKV) infection and its associated congenital and other neurological disorders, particularly microcephaly and other fetal developmental abnormalities, constitute a World Health Organization (WHO) Zika Virus Research Agenda within the WHO’s R ...
Márquez-Arce, Daniel +15 more
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Immunological genomics of Brugia malayi:filarial genes implicated in immune evasion and protective immunity [PDF]
, 2001 Filarial nematodes are metazoan parasites with genome sizes of> 100 million base pairs, probably encoding 15 000-20 000 genes. Within this considerable gene complement, it seems likely that filariae have evolved a spectrum of immune evasion products ...
Scott, Alan +3 more
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L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes [PDF]
, 2023 Malignant tumors often escape anticancer immune surveillance by suppressing the cytotoxic functions of T lymphocytes. While many of these immune evasion networks include checkpoint proteins, small molecular weight compounds, such as the amino acid L ...
Elena Klenova +23 more
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Unveiling TNFAIP8L2-related immune evasion mechanisms in colorectal cancer [PDF]
Colorectal cancer (CRC) remains to be a leading cause of cancer-related mortality worldwide. Although immune evasion appears to play a critical role in CRC progression, the underlying mechanisms are poorly defined, necessitating further scientific ...
Li, P. +7 more
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Escape from immunotherapy: possible mechanisms that influence tumor regression/progression [PDF]
, 2004 Tumor escape is one major obstacle that has to be addressed prior to designing and delivering successful immunotherapy. There is compelling evidence to support the notion that immunogenic tumors, in murine models and cancer patients, can be rejected by ...
Ahmad, M, Ali, SA, Rees, RC
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Immune evasion during varicella zoster virus infection of keratinocytes
, 2009 Summary T cells are sensitized during varicella-zoster virus (VZV) infection and are important for control of viral spread and reactivation.
Malavige, G.N. +3 more
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Immune evasion by cancer stem cells [PDF]
Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have successfully improved outcomes in several tumor types. In addition, currently, immune cell-based therapy is also attracting significant attention.
00403402 +11 more
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, 2012 peer-reviewedViruses establishing persistent latent infections have evolved various mechanisms to avoid immune surveillance. The Epstein-Barr virus-encoded nuclear antigen, EBNA1, expressed in all EBV-associated malignancies, modulates its own protein ...
David J Lynn +14 more
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Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b
, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel +17 more
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