Results 21 to 30 of about 149,399 (260)
Targeting PIM Kinases to Improve the Efficacy of Immunotherapy
Cells, 2022 The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of serine/threonine kinases that regulates numerous signaling networks that promote cell growth, proliferation, and survival.
Amber N. Clements, Noel A. Warfel
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Human cytomegalovirus immunity and immune evasion
Virus Research, 2011 Human cytomegalovirus (HCMV) infection induces both innate immune responses including Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ cytotoxic and γδ T cell) responses which lead to the resolution of acute primary infection.
Sarah E, Jackson +2 more
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Viral mechanisms of immune evasion [PDF]
Immunology Today, 2000 During the millions of years they have coexisted with their hosts, viruses have learned how to manipulate host immune control mechanisms. Viral gene functions provide an overview of many relevant principles in cell biology and immunology. Our knowledge of viral gene functions must be integrated into virus-host interaction networks to understand viral ...
Alcami, Antonio, Koszinowski, Ulrich H.
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Subversion of Immune Response by Human Cytomegalovirus
Frontiers in Immunology, 2019 Human cytomegalovirus (HCMV) is the most common cause of congenital infections and is an important pathogen in immunocompromised individuals. Despite a robust host immune system, HCMV able to replicate, evade host defenses, establish latency for life.
A. Raj Kumar Patro
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Lymphoma: Immune Evasion Strategies [PDF]
Cancers, 2015 While the cellular origin of lymphoma is often characterized by chromosomal translocations and other genetic aberrations, its growth and development into a malignant neoplasm is highly dependent upon its ability to escape natural host defenses.
Upadhyay, Ranjan +5 more
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Immune subtypes and neoantigen-related immune evasion in advanced colorectal cancer
iScience, 2022 Summary: Elimination of cancerous cells by the immune system is an important mechanism of protection from cancer, however, its effectiveness can be reduced owing to development of resistance and evasion.
Toshitaka Sugawara +11 more
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Immune evasion mechanisms of arenaviruses
Oncotarget, 2015 Arenaviruses, such as Lassa virus (LASV), can cause fatal human hemorrhagic fever (HF) diseases for which licensed vaccines and effective therapies are currently unavailable [1]. These viruses have been shown to initiate the infection by targeting the antigen presenting cells (APCs), such as dendritic (DC) and macrophage (MP) cells [1].
Hinh, Ly, Yuying, Liang
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AutoimmunityThe advancement of hepatocellular carcinoma (HCC) is associated with metabolic reprogramming and immune escape. Compound kushen injection (CKI) is a cancer therapeutic agent with a long history.
Zhuo Lv +4 more
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Annual Review of ImmunologyPoxviruses have evolved a wide array of mechanisms to evade the immune response, and we provide an overview of the different immunomodulatory strategies. Poxviruses prevent the recognition of viral DNA that triggers the immune responses and inhibit signaling pathways within the infected cell. A unique feature of poxviruses is the production of secreted
Hernáez, Bruno, Alcamí, Antonio
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Immune System Evasion Mechanisms in Staphylococcus aureus: Current Understanding
Journal of Pure and Applied Microbiology, 2020 Staphylococcus aureus is a major human pathogen that may cause a wide range of infections and is a frequent cause of soft tissue and bloodstream infections.
Hesham A. Malak +13 more
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