Results 21 to 30 of about 155,116 (264)

Viral miRNAs and immune evasion [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011
Viral miRNAs, ~22nt RNA molecules which post-transcriptionally regulate gene expression, are emerging as important tools in immune evasion. Viral infection is a complex process that requires immune evasion in order to establish persistent life-long infection of the host.
Department of Molecular Genetics and Microbiology, University of Florida Mowry Road, Gainesville, FL 32610, USA ( host institution ), Boss, Isaac W. ( author ), Renne, Rolf ( author )   +2 more
openaire   +3 more sources

Immune evasion mechanisms of arenaviruses

Oncotarget, 2015
Arenaviruses, such as Lassa virus (LASV), can cause fatal human hemorrhagic fever (HF) diseases for which licensed vaccines and effective therapies are currently unavailable [1]. These viruses have been shown to initiate the infection by targeting the antigen presenting cells (APCs), such as dendritic (DC) and macrophage (MP) cells [1].
Hinh, Ly, Yuying, Liang
openaire   +2 more sources

Immune Evasion Strategies of Glioblastoma [PDF]

Frontiers in Surgery, 2016
Glioblastoma (GBM) is the most devastating brain tumor, with associated poor prognosis. Despite advances in surgery and chemoradiation, the survival of afflicted patients has not improved significantly in the past three decades. Immunotherapy has been heralded as a promising approach in treatment of various cancers; however, the immune privileged ...
Razavi, Seyed-Mostafa, Lee, Karen E., Jin, Benjamin E., Aujla, Parvir S., Gholamin, Sharareh, Li, Gordon   +5 more
openaire   +3 more sources

Poxvirus Immune Evasion

Annual Review of Immunology
Poxviruses have evolved a wide array of mechanisms to evade the immune response, and we provide an overview of the different immunomodulatory strategies. Poxviruses prevent the recognition of viral DNA that triggers the immune responses and inhibit signaling pathways within the infected cell. A unique feature of poxviruses is the production of secreted
Hernáez, Bruno, Alcamí, Antonio
openaire   +3 more sources

Lymphoma: Immune Evasion Strategies [PDF]

Cancers, 2015
While the cellular origin of lymphoma is often characterized by chromosomal translocations and other genetic aberrations, its growth and development into a malignant neoplasm is highly dependent upon its ability to escape natural host defenses.
Upadhyay, Ranjan, Hammerich, Linda, Peng, Paul, Brown, Brian, Merad, Miriam, Brody, Joshua D.   +5 more
openaire   +2 more sources

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP

, 2008
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Wiertz, E.J.H.J., Rezende, Marisa Marcondes, Thomas C Mettenleiter, Jacques J Neefjes, Wang, Ying, Koch, J., Mirjam H M Heemskerk, Loch Sandra, Marieke C Verweij, Daus, Franz, Nikolaus Osterrieder, Neefjes, J.J., Tampe, R., Chowdhury, Shafiqul I., Osterrieder, Nikolaus, Loch, S., Edwin Quinten, Rijsewijk, Frans A. M., Quinten, E., Neefjes, Jacques J., Ressing, Maaike E., Lipinska, A.D., Krystyna Bieńkowska-Szewczyk, Verweij Marieke C., Koch Joachim, Danijela Koppers-Lalic, Neefjes Jacques J., Wiertz, Emmanuel J. H. J., Koppers-Lalic, Danijela, Mettenleiter, T.C., Lipińska Andrea D., Rezende Marisa Marcondes, Ressing Maaike E., Emmanuel J H J Wiertz, Lipinska, Andrea D., Tampé Robert, Verweij, M.C., Ressing, M.E., Ying Wang, Wang, Y., Koch, Joachim, Heemskerk, Mirjam H. M., Sandra Loch, Marisa Marcondes Rezende, Tampé, Robert, Daus, F.J., Reits, E.A., Wiertz Emmanuel J. H. J., Shafiqul I Chowdhury, Loch, Sandra, Koppers-Lalic Danijela, Osterrieder, N., Quinten, Edwin, Rezende, M.M., Robert Tampé, Verweij, Marieke C., Joachim Koch, Franz Daus, Mettenleiter Thomas C., Bienkowska-Szewczyk, K., Rijsewijk, F.A.M., Eric A Reits, Heemskerk Mirjam H. M., Mettenleiter, Thomas C., Maaike E Ressing, Reits Eric A., Marcondes Rezende, Marisa, Chowdhury, S.I., Osterrieder Nikolaus, Daus Franz, Quinten Edwin, Koppers-Lalic, D., Reits, Eric A., Bienkowska-Szewczyk, Krystyna, Andrea D Lipińska, Frans A M Rijsewijk, Bieńkowska-Szewczyk Krystyna, Wang Ying, Rijsewijk Frans A. M., Heemskerk, M.H.M., Chowdhury Shafiqul I.   +80 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Immune System Evasion Mechanisms in Staphylococcus aureus: Current Understanding

, 2020
Staphylococcus aureus is a major human pathogen that may cause a wide range of infections and is a frequent cause of soft tissue and bloodstream infections.
Ashwag Shami, Wafa A. Alshehri, Khaled Elbanna, Hiyam H. Abureesh, Hussein H. Abulreesh, Iqbal Ahmad, Ashjan Khalel, Mohammad S. Aldosari, Mohammed R. Shaaban, Sameer R. Organji, Hesham A. Malak, Fatimah H. Asiri, Meshal H.K. Almalki, Samreen   +13 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]

, 2009
Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul, Johannsen, Eric, Haas, Juergen, Hyun Joo, Chul, Fossum, Even, Hutt-Fletcher, Lindsay M., Wu, L., Inn, Kyung-Soo, Jung, Jae U.   +8 more
core   +1 more source