Immune System Evasion Mechanisms in Staphylococcus aureus: Current Understanding
Journal of Pure and Applied Microbiology, 2020 Staphylococcus aureus is a major human pathogen that may cause a wide range of infections and is a frequent cause of soft tissue and bloodstream infections.
Hesham A. Malak +13 more
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Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo. [PDF]
, 2014 Staphylococcus aureus is a commensal and major pathogen of humans and animals. Comparative genomics of S. aureus populations suggests that colonization of different host species is associated with carriage of mobile genetic elements (MGE), particularly ...
Gould, KA +5 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Human cytomegalovirus immunity and immune evasion
Virus Research, 2011 Human cytomegalovirus (HCMV) infection induces both innate immune responses including Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ cytotoxic and γδ T cell) responses which lead to the resolution of acute primary infection.
Sarah E, Jackson +2 more
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Characteristics of Staphylococcus aureus infections to consider in designing an effective vaccine. [PDF]
, 2010 _Staphylococcus aureus_ is a very versatile and adaptable microorganism. It can potentially infect virtually any host tissue. Given the appropriate conditions it can become a life-threatening pathogen, or a commensal colonizer of the nose.
Beatriz E. Baca +2 more
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A new landscape of host–protozoa interactions involving the extracellular vesicles world [PDF]
, 2018 This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © Cambridge University Press 2018Extracellular vesicles (EVs) are released by a wide number of cells including ...
Bruno Gavinho +11 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Neuroimmune Evasion of Zika Virus to Facilitate Viral Pathogenesis
Frontiers in Cellular and Infection Microbiology, 2021 Zika virus (ZIKV), which preferentially targets neural stem and progenitor cells (NSCs) especially in developing brain, is causally associated with fetal microcephaly, intrauterine retardation, and other congenital malformations in humans. However, there
Xiaochun Xie +3 more
doaj +1 more source
Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): downregulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms [PDF]
, 1993 Mice were infected either with Trichinella spiralis (day 0), Heligmosomoides polygyrus (day -14) or concurrently with both species and were killed in groups, together with naive control mice, on 2 occasions (day 8 and 15 post infection with T.
Behnke, Jerzy M. +5 more
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Engineering immune evasion [PDF]
Nature, 2006 One obstacle to realizing the promise of viral vectors for vaccine delivery is pre-existing immunity to such vectors. An adroit application of structure-based design points to a way around that problem.
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