Results 51 to 60 of about 1,246,147 (266)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Immune Evasion of Enteroviruses Under Innate Immune Monitoring

Frontiers in Microbiology, 2018
As a major component of immunological defense against a great variety of pathogens, innate immunity is capable of activating the adaptive immune system.
Ying Zhang, Jingyan Li, Qihan Li
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Complex pattern of immune evasion in MSI colorectal cancer

OncoImmunology, 2018
Mismatch repair (MMR)-deficient cancers accumulate multiple insertion/deletion mutations at coding microsatellites (cMS), which give rise to frameshift peptide neoantigens.
Mine Ozcan, Jonas Janikovits, Magnus von Knebel Doeberitz, Matthias Kloor   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Tax Evasion in the Philippines, 1981-1985 [PDF]

From the administrative and policy perspective, determination of magnitude of tax evasion and an analysis of tax evasion levels are imperative so that authorities may evaluate the success or failure of the enforcement mechanism.
Manasan, Rosario G.
core   +2 more sources

CoCl2‐induced glioma hypoxia environment enhances CD47‐SIRPα to promote tumor immune evasion

MedComm – Oncology
Elevated levels of tumor‐associated macrophages and microglia in the immune microenvironment of malignant gliomas promote tumor growth and progression.
Xiangfei Ding, Jianbing Hou, Xiaosong Hu, Wen Peng, Yongsen Li, Gaichao Zhao, Hongjuan Cui, Zonghui Wu, Ping Liang   +8 more
doaj   +1 more source

Alum Activates the Bovine NLRP3 Inflammasome

Frontiers in Immunology, 2017
There has been a move away from vaccines composed of whole or inactivated antigens toward subunit-based vaccines, which although safe, provide less immunological protection.
Ciaran Harte, Ciaran Harte, Aoife L. Gorman, S. McCluskey, Michael Carty, Andrew G. Bowie, C. J. Scott, Kieran G. Meade, Ed C. Lavelle   +8 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection [PDF]

, 2006
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect of this host ...
Cheng, Wendy, Battegay, Manuel, E. Freitas, Weber, R., Furrer, H., Jeffrey, G., James, Ian, Park, Lawrence P, Swiss HIV Cohort Study,, G. Jeffrey, Battegay, M., Jeffrey, Gary, Herrmann, S., James, I., Weber, R., Battegay, M., Chapman, R., S. Herrmann, Furrer, Hansjakob, Telenti, Amalio, Freitas, E., Telenti, A., Lucas, M., M. Lucas, null null, I. James, Weber, Rainer, Telenti, A., Lucas, M., Freitas, Elizabeth, H. Furrer, Cheng, W., Jeffrey, G., Gaudieri, S., S. A. Mallal, Park, P., Freitas, E., Cheng, W., K. Pfafferott, Pfafferott, K., S. Gaudieri, R. Weber, Naidoo, Kiloshni, A. Rauch, Pfafferott, K., Mallal, Simon A, L. P. Park, Rauch, A., Chapman, R., A. Telenti, Pfafferott, Katja, R. Chapman, Lucas, Michaela, M. Battegay, Park, L.P., Naidoo, K., Herrmann, Susan, K. Naidoo, Furrer, H., Rauch, Andri, Park, L. P., W. Cheng, Herrmann, S., Naidoo, K., Chapman, Russell, Rauch, A., Mallal, S.A., Gaudieri, S., Mallal, S. A., James, I., Gaudieri, Silvana   +70 more
core   +1 more source