Results 21 to 30 of about 381,426 (191)
NKG2D Ligand Shedding in Response to Stress: Role of ADAM10 [PDF]
Frontiers in Immunology, 2020 NKG2D is an activating receptor expressed by NK cells and some subsets of T cells and represents a major recognition receptor for detection and elimination of cancer cells.
Alessandra Zingoni +4 more
doaj +4 more sources
Cervical cancer cell lines expressing NKG2D-ligands are able to down-modulate the NKG2D receptor on NKL cells with functional implications [PDF]
BMC Immunology, 2012 Background Cervical cancer represents the third most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths in women worldwide.
Jimenez-Perez Miriam I +9 more
doaj +2 more sources
Leveraging NKG2D Ligands in Immuno-Oncology. [PDF]
Front Immunol, 2021 Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened new avenues towards the development of novel assets to achieve durable immune control of cancer. Yet, the presence of tumor immune evasion mechanisms represents a challenge for the development of efficient treatment options.
Fuertes MB, Domaica CI, Zwirner NW.
europepmc +6 more sources
mAbsNatural killer (NK) cells are effector cells of the innate immune system that distinguish between healthy and abnormal cells through activating and inhibitory receptor signaling.
Daniel Fallon +4 more
doaj +2 more sources
A Concise Review of the Role of the NKG2D Receptor and Its Ligands in Cancer
ImmunoThe immune system’s ability to detect and eliminate transformed cells is a critical factor in suppressing cancer development. However, immune surveillance in tumors is often disrupted by various immune escape mechanisms, many of which remain poorly ...
Elitsa Boneva +2 more
doaj +2 more sources
NKG2D Receptor and Its Ligands in Host Defense [PDF]
Cancer Immunology Research, 2015 NKG2D is an activating receptor expressed on the surface of natural killer (NK) cells, CD8(+) T cells, and subsets of CD4(+) T cells, invariant NKT cells (iNKT), and γδ T cells. In humans, NKG2D transmits signals by its association with the DAP10 adapter
Lanier, Lewis L,, Lanier, Lewis L
core +6 more sources
How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation. [PDF]
Front Immunol, 2017 Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions.
Antonangeli F +4 more
europepmc +7 more sources
Alterations of NKG2D/ligands pathway in IBD
, 2008 Background. The mucosal immune system balances the need of co-existing with commensal flora and food antigens while responding to pathogens. Inflammatory bowel disease (IBD), comprising Crohn disease (CD) and ulcerative colitis (UC), is a chronic inflam-
CUCCHIARA, Salvatore +9 more
core +4 more sources
Targeting the NKG2D axis in head and neck squamous cell carcinoma: from molecular insights to clinical applications [PDF]
Cancer Cell InternationalHead and neck squamous cell carcinoma (HNSCC) is an aggressive cancer that evades immune surveillance by impairing the NKG2D receptor on natural killer (NK) cells and cytotoxic T lymphocytes.
Parsa Alijanizadeh +8 more
doaj +2 more sources
The mIRNA519a-3p and NKG2D in endometriosis.
Indonesian Journal of Obstetrics and Gynecology, 2022 Background: Natural killer (NK) cells play a role in pathogenesis of endometriosis. Lower expressions of NK cells receptor group 2D (NKG2D) ligands inhibits cytotoxic activity of NK cells; a common immunity avoidance mechanism in neoplasms.
Cepi Teguh Pramayadi +3 more
doaj +1 more source