Frontiers in Immunology, 2018 Natural-killer group 2 member D (NKG2D) is a well-characterized activating receptor expressed by natural killer (NK) cells, NKT cells, activated CD8+ T cells, subsets of γδ+ T cells, and innate-like T cells.
Shuhei Hosomi +6 more
doaj +2 more sources
Endothelial cells express NKG2D ligands and desensitize antitumor NK responses. [PDF]
Elife, 2017 Natural Killer (NK) cells confer protection from tumors and infections by releasing cytotoxic granules and pro-inflammatory cytokines upon recognition of diseased cells.
Thompson TW +7 more
europepmc +2 more sources
Molecular bases for the regulation of NKG2D ligands in cancer [PDF]
Frontiers in Immunology, 2014 NKG2D is an activating receptor expressed by NK and T cells primarily involved in the elimination of transformed and infected cells. NKG2D ligands are self-proteins restrictedly expressed in healthy tissues, but induced in response to signaling pathways ...
Leticia eHuergo-Zapico +5 more
doaj +4 more sources
The Biological Influence and Clinical Relevance of Polymorphism Within the NKG2D Ligands. [PDF]
Front Immunol, 2018 NKG2D is a major regulator of the activity of cytotoxic cells and interacts with eight different ligands (NKG2DL) from two families of MIC and ULBP proteins.
Zuo J, Mohammed F, Moss P.
europepmc +2 more sources
Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells. [PDF]
Oncoimmunology, 2018 Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated.
Maurer S +9 more
europepmc +2 more sources
The combination of ionizing radiation and proteasomal inhibition by bortezomib enhances the expression of NKG2D ligands in multiple myeloma cells. [PDF]
J Radiat Res, 2018 Bortezomib, which is a potent proteasome inhibitor, has been used as a first-line drugs to treat multiple myeloma for a few decades, and radiotherapy has frequently been applied to manage acute bone lesions in the patients. Therefore, it was necessary to
Lee YS, Heo W, Nam J, Jeung YH, Bae J.
europepmc +2 more sources
Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia [PDF]
The Journal of Clinical Investigation, 2022 Fanconi anemia (FA) is the most prevalent inherited bone marrow failure (BMF) syndrome. Nevertheless, the pathophysiological mechanisms of BMF in FA have not been fully elucidated.
José A. Casado +15 more
doaj +2 more sources
Disarming Cellular Alarm Systems-Manipulation of Stress-Induced NKG2D Ligands by Human Herpesviruses. [PDF]
Front Immunol, 2017 The coevolution of viruses and their hosts led to the repeated emergence of cellular alert signals and viral strategies to counteract them. The herpesvirus family of viruses displays the most sophisticated repertoire of immune escape mechanisms enabling ...
Schmiedel D, Mandelboim O.
europepmc +2 more sources
NKG2D Ligand Shedding in Response to Stress: Role of ADAM10 [PDF]
Frontiers in Immunology, 2020 NKG2D is an activating receptor expressed by NK cells and some subsets of T cells and represents a major recognition receptor for detection and elimination of cancer cells.
Alessandra Zingoni +4 more
doaj +4 more sources
Natural Killer Group 2, Member D/NKG2D Ligands in Hematopoietic Cell Transplantation
Frontiers in Immunology, 2017 Natural killer group 2, member D (NKG2D) is an invariant activatory receptor present on subsets of natural killer and T lymphocytes. It stimulates the cytolytic effector response upon engagement of its various stress-induced ligands NKG2D ligands (NKG2DL)
Christine Carapito +2 more
exaly +2 more sources