Expressions of natural cytotoxicity receptor, NKG2D and NKG2D ligands in endometriosis
Journal of Reproductive Immunology, 2019 Pathogenesis of endometriosis is still unknown, and the relationship between NK cell activating receptors and endometriosis remains to be explored. We investigated the expression of NCRs and NKG2D in NK cells in peripheral blood (PB) and peritoneal fluid
Hong Xu
exaly +4 more sources
NKG2D ligands mediate immunosurveillance of senescent cells. [PDF]
Aging (Albany NY), 2016 Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue damage. Induction of cellular senescence commonly coincides with an immunogenic phenotype that promotes self-elimination by components of the immune system, thereby ...
Sagiv A +8 more
europepmc +6 more sources
NKG2D and Its Ligands: “One for All, All for One” [PDF]
Frontiers in Immunology, 2018 The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with ...
Alessandra Soriani +2 more
exaly +5 more sources
How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation. [PDF]
Front Immunol, 2017 Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions.
Antonangeli F +4 more
europepmc +7 more sources
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. [PDF]
Nature, 2019 Patients with acute myeloid leukaemia (AML) often achieve remission after therapy, but subsequently die of relapse1 that is driven by chemotherapy-resistant leukaemic stem cells (LSCs)2,3.
Paczulla AM +26 more
europepmc +2 more sources
The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition [PDF]
Frontiers in Immunology, 2021 The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat +5 more
doaj +2 more sources
Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality [PDF]
Frontiers in Immunology, 2023 In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which reovirus was used for the treatment of melanoma and glioblastoma, have paved the way for future ...
Raghad Khaleafi +6 more
doaj +2 more sources
OncoImmunology, 2017 The immune receptor NKG2D is predominantly expressed on NK cells and T cell subsets and confers anti-tumor activity. According to the current paradigm, immune surveillance is counteracted by soluble ligands shed into the microenvironment, which down ...
Maulik Vyas +8 more
doaj +2 more sources
cGAS/STING-mediated upregulation of NKG2D ligands in LSCs contributes to enhanced sensitivity to NK cells [PDF]
Frontiers in OncologyIntroductionNatural killer (NK) cells-mediated immune surveillance is essential role for tumor recognition and elimination. The binding of NK group 2 member D (NKG2D) ligands to NKG2D receptor is sufficient to activate the NK cells' cytotoxicity against ...
Yan Ouyang +7 more
doaj +2 more sources
Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma. [PDF]
Cancer Immunol Res, 2019 NKG2D-CAR T-cell therapy is safe and feasible. Infused cells were transiently detected and exhibited in vitro responses to autologous tumors. However, objective responses to low doses were only seen in lymphodepleted patients, warranting studies to ...
Baumeister SH +20 more
europepmc +2 more sources