NKG2D and Its Ligands: “One for All, All for One” [PDF]
Frontiers in Immunology, 2018 The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with ...
Alessandra Zingoni +7 more
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Molecular bases for the regulation of NKG2D ligands in cancer [PDF]
Frontiers in Immunology, 2014 NKG2D is an activating receptor expressed by NK and T cells primarily involved in the elimination of transformed and infected cells. NKG2D ligands are self-proteins restrictedly expressed in healthy tissues, but induced in response to signaling pathways ...
Leticia eHuergo-Zapico +5 more
doaj +6 more sources
New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1 [PDF]
Frontiers in Immunology, 2018 Natural-killer group 2 member D (NKG2D) is a well-characterized activating receptor expressed by natural killer (NK) cells, NKT cells, activated CD8+ T cells, subsets of γδ+ T cells, and innate-like T cells.
Shuhei Hosomi +6 more
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, 2013 NK cell transplantation has been increasingly used to treat cancers that are resistant to chemotherapy. However, not all cancers are susceptible to NK cell killing.
Gupta, Neha Das, Neha Gupta
core +2 more sources
Human NKG2D-ligands: cell biology strategies to ensure immune recognition [PDF]
Frontiers in Immunology, 2012 Immune recognition mediated by the activating receptor NKG2D plays an important role for the elimination of stressed cells, including tumours and virus-infected cells.
Lola eFernández-Messina +2 more
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Regulation of ligands for the activating receptor NKG2D.
Immunology, 2007 The outcome of an encounter between a cytotoxic cell and a potential target cell depends on the balance of signals from inhibitory and activating receptors.
Mistry, AR, O'Callaghan, Christopher
core +5 more sources
Pseudorabies Virus Infection Causes Downregulation of Ligands for the Activating NK Cell Receptor NKG2D [PDF]
Viruses, 2021 Herpesviruses display a complex and carefully balanced interaction with important players in the antiviral immune response of immunocompetent natural hosts, including natural killer (NK) cells.
Sofie Denaeghel +3 more
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NKG2D Ligands in Tumor Immunity: Two Sides of a Coin [PDF]
Frontiers in Immunology, 2015 The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is expressed on the surface of all human NK, NKT, CD8+ T and subsets of γδ+ T cells.
Jennifer eWu +2 more
doaj +2 more sources
NKG2D ligands mediate immunosurveillance of senescent cells. [PDF]
Aging (Albany NY), 2016 Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue damage. Induction of cellular senescence commonly coincides with an immunogenic phenotype that promotes self-elimination by components of the immune system, thereby ...
Sagiv A +8 more
europepmc +6 more sources
Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation [PDF]
Frontiers in Immunology, 2021 Natural killer cells possess key regulatory function in various malignant diseases, including acute myeloid leukemia. NK cell activity is driven by signals received through ligands binding activating or inhibitory receptors.
Alena Machuldova +9 more
doaj +2 more sources