Results 51 to 60 of about 21,131 (181)
Manipulation of NKG2D ligands by cytomegaloviruses: impact on innate and adaptive immune response
Frontiers in Immunology, 2011 NKG2D is a potent activating receptor expressed on NK cells, NKT cells, γδ T cells and CD8 T cells. NKG2D recognizes cell surface molecules structurally related to MHC class I proteins induced by infection or other type of cellular stress. The engagement
Stipan eJonjic
doaj +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Prostate tumor-derived exosomes down-regulate NKG2D expression on natural killer cells and CD8+ T cells: mechanism of immune evasion. [PDF]
PLoS ONE, 2014 Tumor-derived exosomes, which are nanometer-sized extracellular vesicles of endosomal origin, have emerged as promoters of tumor immune evasion but their role in prostate cancer (PC) progression is poorly understood.
Marie Lundholm +6 more
doaj +1 more source
Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma
The FEBS Journal, EarlyView.IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture +3 more
wiley +1 more source
Expressions of natural cytotoxicity receptor, NKG2D and NKG2D ligands in endometriosis
Journal of Reproductive Immunology, 2019 Pathogenesis of endometriosis is still unknown, and the relationship between NK cell activating receptors and endometriosis remains to be explored. We investigated the expression of NCRs and NKG2D in NK cells in peripheral blood (PB) and peritoneal fluid (PF) as well as expression of NKG2D ligands in endometrial cells, and illuminated their ...
openaire +2 more sources
Understanding Exosomes in Hair Regeneration
Periodontology 2000, EarlyView.Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad +3 more
wiley +1 more source
Reviews in Medical Virology, Volume 36, Issue 5, September 2026.ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria +5 more
wiley +1 more source
The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma
Nature Communications, 2017 Expression of NKG2D immunoreceptor ligands on tumour cells is believed to inhibit tumour growth through engaging NKG2D-expressing immune cells. Here, the authors show that in a model of liver cancer the NKG2D/NKG2D-ligand pathway can also promote tumour ...
Sam Sheppard +8 more
doaj +1 more source
Cancer Innovation, Volume 5, Issue 4, August 2026.Innate immune cells (IICs) are not only as first‐line defenders or simple auxiliaries to adaptive immunity, but also as decisive regulators of non‐small cell lung cancer progression and treatment outcomes. ABSTRACT As a leading cause of cancer‐related morbidity and mortality worldwide, non‐small cell lung cancer (NSCLC) is profoundly influenced by ...
Jiaxin Liu +8 more
wiley +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, Volume 40, Issue 8, Page 4759-4791, August 2026.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source