Results 71 to 80 of about 21,131 (181)

NKG2D knockdown improves hypoxic-ischemic brain damage by inhibiting neuroinflammation in neonatal mice

Scientific Reports
Hypoxic-ischemic brain damage (HIBD) is a leading cause of neonatal death and neurological dysfunction. Neuroinflammation is identified as one of the crucial pathological mechanisms after HIBD, and natural killer group 2 member D (NKG2D) is reported to ...
Lin Liu, Yuxin Yang, Ting Wu, Junrong Du, Fangyi Long   +4 more
doaj   +1 more source

MULT1-Encoding DNA Alleviates Schistosomiasis-Associated Hepatic Fibrosis via Modulating Cellular Immune Response

Journal of Inflammation Research, 2022
Lu Yang,1,* Li Sun,1 Yalan Cao,1 Qi Wang,1,2 Anni Song,1 Ru Zhu,1 Wenqi Liu,1 Shengjun Lu1,* 1Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s ...
Yang L, Sun L, Cao Y, Wang Q, Song A, Zhu R, Liu W, Lu S   +7 more
doaj  

Expression and Clinical Significance of CD8+Natural Killer T Cell Stimulatory Receptor NKG2D in Peripheral Blood of Lung Cancer Patients

Chinese Journal of Lung Cancer, 2010
Background and objective NKG2D-expressing CD8+NKT cells and soluble major histocompatibility complex class I-related chain A (sMICA) is one of recently emerged general interests in tumor research area.
Ni CHENG, Fucai HAN, Yanfeng WANG, Xianxia MAI, Wen SU   +4 more
doaj  

Combinatorial therapy with resveratrol sensitizes glioblastoma to NKG2D CAR-T cells

Frontiers in Immunology
Chimeric antigen receptor T-cell (CAR-T) therapies have shown potential in clinical trials for glioblastoma, yet treatment responses vary due to heterogeneous antigen expression and post-treatment immune escape.
Wei Liang, Wei Liang, Yexiao Tang, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Cuimei Chen, Zhiming Xu, Shu Xu, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan   +13 more
doaj   +1 more source

Impaired NK cell recognition of vemurafenib-treated melanoma cells is overcome by simultaneous application of histone deacetylase inhibitors

OncoImmunology, 2018
Therapy of metastatic melanoma advanced recently with the clinical implementation of signalling pathway inhibitors, such as vemurafenib, specifically targeting mutant BRAFV600E.
Sheila López-Cobo, Natalia Pieper, Carmen Campos-Silva, Eva M. García-Cuesta, Hugh T. Reyburn, Annette Paschen, Mar Valés-Gómez   +6 more
doaj   +1 more source

Impairment of NKG2D-Mediated Tumor Immunity by TGF-β

Frontiers in Immunology, 2019
Transforming growth factor-β (TGF-β) suppresses innate and adaptive immune responses via multiple mechanisms. TGF-β also importantly contributes to the formation of an immunosuppressive tumor microenvironment thereby promoting tumor growth.
Mariya Lazarova, Alexander Steinle
doaj   +1 more source

Immune evasion by proteolytic shedding of natural killer group 2, member D ligands in Helicobacter pylori infection

Frontiers in Immunology
BackgroundHelicobacter pylori (H. pylori) uses various strategies that attenuate mucosal immunity to ensure its persistence in the stomach. We recently found evidence that H. pylori might modulate the natural killer group 2, member 2 (NKG2D) system.
Margit Anthofer, Markus Windisch, Rosa Haller, Sandra Ehmann, Sebastian Wrighton, Michael Miller, Lorenz Schernthanner, Iris Kufferath, Silvia Schauer, Barbara Jelušić, Sabine Kienesberger, Sabine Kienesberger, Ellen L. Zechner, Ellen L. Zechner, Gernot Posselt, Mar Vales-Gomez, Hugh T. Reyburn, Gregor Gorkiewicz, Gregor Gorkiewicz   +18 more
doaj   +1 more source

Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells

Journal of Hematology & Oncology, 2018
Background Triple-negative breast cancer (TNBC) is an aggressive disease that currently lacks effective targeted therapy. NKG2D ligands (NKG2DLs) are expressed on various tumor types and immunosuppressive cells within tumor microenvironments, providing ...
Yali Han, Wei Xie, De-Gang Song, Daniel J. Powell   +3 more
doaj   +1 more source

The Role of the NKG2D in Vitiligo.

Frontiers in immunology, 2021
Vitiligo is an acquired multifactorial disease that affects melanocytes and results in skin depigmentation. In this review, we examine the role of cells stress and self-reactive T cells responses. Given the canonical and non-canonical functions of NKG2D, such as authenticating stressed target and enhance TCR signaling, we examine how melanocyte stress ...
Lourdes, Plaza-Rojas, José A, Guevara-Patiño   +1 more
openaire   +1 more source

Advances in NKG2D Receptor-Ligand Axis in Solid Tumor Immunotherapy

Zhongliu Fangzhi Yanjiu
The NKG2D receptor-ligand axis is a major pathway through which natural killer (NK) cells and subsets of effector T cells recognize stressed or malignant cells; thus, it plays an important role in immune surveillance, immune evasion and therapeutic ...
Qinpei CHENG, Tangfeng LYU
doaj   +1 more source