Results 61 to 70 of about 22,145 (200)

DISTRIBUTION OF MICA ALLELES IN THE RUSSIAN POPULATION

Медицинская иммунология, 2019
Stress factors, infections, tumor transformation of the cells of organism induce the expression of MICA protein, which is a ligand for the NKG2D receptor of NK and T cells.
L. M. Kanevskiy, M. V. Grechikhina, E. G. Kuzmina, T. Yu. Mushkarina, A. A. Spelkov, M. A. Streltsova, E. I. Kovalenko   +6 more
doaj   +1 more source

TIM‐3 Functions as an Activator of NK Cells in GBM and Can Be Upregulated by Torin‐1: Implications for Exogenous NK Cell Transplantation

Immunology, EarlyView.
Unlike generalized mTOR inhibitors, Torin‐1 uniquely drives compensatory upregulation of TIM‐3 on human NK cells, shielding them from immunosuppression while concurrently inhibiting glioblastoma (GBM) growth. Selecting or preconditioning ex vivo NK cell products for high TIM‐3 expression can offer a combination strategy for adoptive cell therapy in GBM.
Yuning Liu, Tram Dao, Shambhavi Borde, Diana Dinh, Sofia Lombardi, Sandra Torregrosa‐Allen, Haley A. Harper, Veronika Slivova, Aaron Cohen‐Gadol, MacKenzie McIntosh, Bennet D. Elzey, Sandro Matosevic   +11 more
wiley   +1 more source

POTENTIAL USAGE OF NK CELLS AND NKG2D-POSITIVE LYMPHOCYTES AS TARGETS IN THERAPY OF CROHN’S DISEASE

Медицинская иммунология, 2017
Autoimmune mechanisms of Crohn’s disease have been extensively  studied, following discovery of NOD2, ATG16L1, IRGM genetic  polymorphisms associated with  Crohn’s disease.
E. A. Shulenina, E. V. Abakushina, E. Yu. Lyssuk   +2 more
doaj   +1 more source

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

The osteoimmune cell atlas of peri‐implantitis: A narrative scoping review

Periodontology 2000, EarlyView.
Abstract Background/Aim Peri‐implantitis represents a complex osteoimmune disorder characterized by dysregulated cellular ecosystems that drive chronic inflammation and accelerated peri‐implant bone loss. Materials and Methods This article was designed as a narrative scoping review to map and integrate the available evidence from transcriptomics ...
Emilio A. Cafferata, Anton Sculean, Frank Schwarz   +2 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Circulating Natural Killer Cells in Patients With Type 2 Diabetes and Peripheral Neuropathy Are Altered in Their Frequency and Exhibit Impaired Functions and Angiogenic Activities

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Neuropathic T2DM is characterized by increased circulating NK‐cell frequency but impaired NK‐cell function. Functional defects, including reduced degranulation and diminished pro‐angiogenic activity, together with an inflammatory cytokine milieu, promote macrophage recruitment, vascular inflammation, and defective angiogenesis, highlighting NK‐cell ...
Maria Teresa Palano, Federica Riccio, Luisa Sambado, Elena Tagliabue, Milena Bertolotti, Marzia Campanile, Martina Mutoli, Fiorenza Lotti, Andrea Rampin, Cristian Rubuano, Giorgia Maspero, Antonio Antico, Francesca Pitzalis, Matteo Fassan, Piero Maria Stefani, Paola Ostano, Giovanna Chiorino, Nicolò Baranzini, Laura Pulze, Annalisa Grimaldi, Antonino Bruno, Maria Sambataro, Gaia Spinetti   +22 more
wiley   +1 more source

Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60.

Immunity, 2001
NKG2D is a potent activating receptor on natural killer cells, T cells, and macrophages. Mouse NKG2D interacts with two cell surface ligands related to class I MHC molecules: RAE1 and H60. We used soluble versions of NKG2D, RAE1, and H60 to characterize their interactions.
O'Callaghan, Christopher A., Cerwenka, Adelheid, Willcox, Benjamin E., Lanier, Lewis L., Bjorkman, Pamela J.   +4 more
openaire   +4 more sources

Membrane‐Bound Multimodal Plasmonic Transducers for Noninvasive, In Situ Monitoring and Control of CAR T Cells Against Heterogeneous Solid Tumors

Advanced Materials, Volume 38, Issue 58, 16 October 2026.
Membrane‐bound multimodal transducers enable longitudinal ultrasound‐guided photoacoustic monitoring and in situ thermal control of CAR T cells in heterogeneous solid tumors. Imaging correlates T cell trafficking with tumor response, distinguishing responders from nonresponders.
Myeongsoo Kim, Ali Zamat, Melissa Cadena, Chloé Thiveaud, Riya Sen, Jeungyoon Lee, Elif Kulaksizoglu, S. Abbey Oliver, Don VanderLaan, Sydney Fábrega, Zizhen Zha, Kelsey P. Kubelick, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +14 more
wiley   +1 more source

Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys

Heliyon
NKG2D and its ligands are critical regulators of protective immune responses controlling infections and cancer, defining a crucial immune signaling axis. Current therapeutic efforts targeting this axis almost exclusively aim at enhancing NKG2D-mediated effector functions.
Peter B. Rupert, Matthew Buerger, Emily J. Girard, Marie Frutoso, Don Parrilla, Kevin Ng, Theodore Gooley, Veronika Groh, Roland K. Strong   +8 more
openaire   +3 more sources