Results 11 to 20 of about 1,498,031 (298)

Inhibitory pattern recognition receptors [PDF]

Journal of Experimental Medicine, 2021
Pathogen- and damage-associated molecular patterns are sensed by the immune system’s pattern recognition receptors (PRRs) upon contact with a microbe or damaged tissue. In situations such as contact with commensals or during physiological cell death, the immune system should not respond to these patterns.
Matevž Rumpret, Helen J. von Richthofen, Victor Peperzak, Linde Meyaard   +3 more
openaire   +3 more sources

Tethered Signaling in Inhibitory Immune Receptors [PDF]

Frontiers in Physics, 2019
Leukocytes play critical roles in preventing pathogenic infection and controlling transformed cells, but must remain quiescent in response to healthy tissue.
Pablo Pérez-Ferreros, Pablo Pérez-Ferreros, Katharina Gaus, Katharina Gaus, Jesse Goyette, Jesse Goyette   +5 more
doaj   +2 more sources

Inhibitory receptors beyond T cell exhaustion [PDF]

Frontiers in Immunology, 2015
Inhibitory receptors (iRs) are frequently associated with T cell exhaustion. However, the expression of iRs is also dependent on T cell differentiation and activation.
Silvia A Fuertes Marraco, Silvia A Fuertes Marraco, Natalie J Neubert, Natalie J Neubert, Gregory eVerdeil, Gregory eVerdeil, Daniel E Speiser, Daniel E Speiser   +7 more
doaj   +5 more sources

Functional categories of immune inhibitory receptors

Nature Reviews Immunology, 2020
The human genome encodes more than 300 potential immune inhibitory receptors. The reason for this large number of receptors remains unclear. We suggest that inhibitory receptors operate as two distinct functional categories: receptors that control the signalling threshold for immune cell activation and receptors involved in the negative feedback of ...
Matevž Rumpret, Julia Drylewicz, Laura J. E. Ackermans, José A. M. Borghans, Ruslan Medzhitov, Linde Meyaard   +5 more
openaire   +3 more sources

Inhibitory opioid receptors in canine pylorus

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1988
In 18 anesthetized dogs, antroduodenal and pyloric motility was monitored in vivo by a sleeve and perfused side-hole manometric assembly and by antral and duodenal serosal strain gauges. Close intra-arterial injection to the pylorus of dynorphin-(1-13) (Dyn) for kappa-receptors, [D-Pen2,5]enkephalin (DPen2,5-Enk) for delta-receptors, and [N-Me-Phe3-D ...
H D, Allescher, S, Ahmad, E E, Daniel, J, Dent, F, Kostolanska, J E, Fox   +5 more
openaire   +3 more sources

Characterisation of bovine leukocyte Ig-like receptors [PDF]

, 2012
Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have ...
Jones, DC, Singh, M, Allen, RL, Trowsdale, J, Laing, K, Butcher, P, Bhuju, S, Hogan, L, Vordermeier, M   +8 more
core   +4 more sources

Inhibitory Glycine Receptors: An Update [PDF]

Journal of Biological Chemistry, 2012
Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently emerging functions of distinct GlyR ...
Dutertre, Sebastien, Becker, Cord-Michael, Betz, Heinrich   +2 more
openaire   +6 more sources

Inhibitory Receptor Diffusion Dynamics [PDF]

Frontiers in Molecular Neuroscience, 2019
The dynamic modulation of receptor diffusion-trapping at inhibitory synapses is crucial to synaptic transmission, stability, and plasticity. In this review article, we will outline the progression of understanding of receptor diffusion dynamics at the plasma membrane.
Stephanie A. Maynard, Antoine Triller
openaire   +3 more sources

Placental growth factor exerts modulatory effects on in vitro activated T cells

Бюллетень сибирской медицины, 2021
Background. Recent studies demonstrated immunosuppressive properties of vascular endothelial growth factor (VEGF-A) and identified VEGF-A as a key mediator of tumor-induced immunosuppression.
E. A. Smetanenko, O. Yu. Leplina, M. A. Tikhonova, N. M. Pasman, A. A. Ostanin, E. R. Chernykh   +5 more
doaj   +1 more source

Inhibitory receptors abound? [PDF]

Proceedings of the National Academy of Sciences, 1997
Receptor biologists have traditionally focused on receptors that are physiologically coupled to inductive responses such as gene expression, cytokinesis, secretion, or entry into the cell cycle. It has generally been assumed that such inductive responses were terminated by ligand decay or receptor desensitization, which lead to cessation of signaling ...
openaire   +2 more sources