Results 41 to 50 of about 1,498,031 (298)

Human Immunodeficiency Virus Type-1 Elite Controllers Maintain Low Co-Expression of Inhibitory Receptors on CD4+ T Cells

Frontiers in Immunology, 2018
Human immunodeficiency virus type-1 (HIV-1) elite controllers (ELCs) represent a unique population that control viral replication in the absence of antiretroviral therapy (cART).
Kajsa Noyan, Son Nguyen, Michael R. Betts, Anders Sönnerborg, Anders Sönnerborg, Marcus Buggert, Marcus Buggert   +6 more
doaj   +1 more source

Identification of serine 867 as new phosphorylation site on the GABA(B) receptor : characterization of physiological effects [PDF]

, 2011
The GABAB receptor is the metabotropic receptor for γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the mammalian central nervous system (CNS). The functional receptor is a heteromer consisting of a GABAB1 and GABAB2 subunit.
Abdel Aziz, Said
core   +1 more source

Natural Killer Cells in the Malignant Niche of Multiple Myeloma

Frontiers in Immunology, 2022
Natural killer (NK) cells represent a subset of CD3- CD7+ CD56+/dim lymphocytes with cytotoxic and suppressor activity against virus-infected cells and cancer cells.
Ondrej Venglar, Ondrej Venglar, Ondrej Venglar, Julio Rodriguez Bago, Julio Rodriguez Bago, Benjamin Motais, Benjamin Motais, Roman Hajek, Roman Hajek, Tomas Jelinek, Tomas Jelinek   +10 more
doaj   +1 more source

Maintaining the Balance: Regulation of NK Cell Activity

Cells
Natural Killer (NK) cells, integral components of the innate immune system, play a crucial role in the protection against intracellular threats. Their cytotoxic power requires that activation is tightly controlled, and in this, they take a unique ...
Vanna Imširović, Felix M. Wensveen, Bojan Polić, Vedrana Jelenčić   +3 more
doaj   +1 more source

An Animal Model of Acute and Chronic Chagas Disease With the Reticulotropic Y Strain of Trypanosoma cruzi That Depicts the Multifunctionality and Dysfunctionality of T Cells

Frontiers in Immunology, 2019
Chagas disease (ChD), a complex and persistent parasitosis caused by Trypanosoma cruzi, represents a natural model of chronic infection, in which some people exhibit cardiac or digestive complications that can result in death 20–40 years after the ...
Jose Mateus, Jose Mateus, Paula Guerrero, Paola Lasso, Paola Lasso, Claudia Cuervo, John Mario González, Concepción J. Puerta, Adriana Cuéllar   +8 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

NK Cell Dysfunction and Checkpoint Immunotherapy

Frontiers in Immunology, 2019
NK cells play important roles in the innate immune responses against tumors. The effector function of NK cells relies on the integration of activating and inhibitory signals.
Jiacheng Bi, Zhigang Tian, Zhigang Tian
doaj   +1 more source

Access of inhibitory neurosteroids to the NMDA receptor [PDF]

British Journal of Pharmacology, 2012
BACKGROUND AND PURPOSENMDA receptors are glutamatergic ionotropic receptors involved in excitatory neurotransmission, synaptic plasticity and excitotoxic cell death. Many allosteric modulators can influence the activity of these receptors positively or negatively, with behavioural consequences.
Jirina, Borovska, Vojtech, Vyklicky, Eva, Stastna, Vojtech, Kapras, Barbora, Slavikova, Martin, Horak, Hana, Chodounska, Ladislav, Vyklicky   +7 more
openaire   +2 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source