Results 61 to 70 of about 1,498,031 (298)
, 2015 IL-15 bound to the IL-15Rα–chain (IL-15Rα) is presented in trans to cells bearing the IL-2Rβ–chain and common γ-chain. As IL-15 transpresentation occurs in the context of cell-to-cell contacts, it has the potential for regulation by and of other receptor–
Tagaya, Yutaka +4 more
core +1 more source
Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Brugger, Stefan +21 more
core +1 more source
CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape
Frontiers in Immunology, 2020 Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for the treatment of hematological malignancies. However, in patients with solid tumors, objective responses to CAR-T cell therapy remain sporadic and transient.
Alba Rodriguez-Garcia +4 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko +5 more
wiley +1 more source
Sensing context: Inhibitory receptors on non-hematopoietic cells [PDF]
, 2023 Similar to immune cells, non-hematopoietic cells recognize microbial and endogenous threats. Their response to these stimuli is dependent on the environmental context.
von Richthofen, Helen J. +5 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess +5 more
wiley +1 more source
Expression of inhibitory receptors on CD4+ and CD8+ T cells from healthy Colombian donors
Universitas Scientiarum, 2012 T cell activation involves positive cellular signals that promote effector functions and negative signals that contribute to the regulationof these responses.
Adriana Cuéllar, Paola Lasso
doaj
Effects of peptide on NK cell-mediated MHC I recognition
Frontiers in Immunology, 2014 The inhibitory receptors for MHC class I have a central role in controlling NK cell activity. Soon after their discovery it was found that these receptors have a degree of peptide selectivity.
Salim Iqbal Khakoo +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh +4 more
wiley +1 more source
Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]
, 2007 Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D. +3 more
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