Results 71 to 80 of about 1,498,031 (298)

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]

, 2007
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Feeney, M, Allgaier, Rachel, Marcus Altfeld, Feeney, Margaret, Williams, KL, Sivamurthy, R, Pereyra, F, Allgaier, R, Rohini Sivamurthy, Stanley K. Mui, Rosenberg, Eric S, Allen, Todd M, Altfeld, M, Eric S. Rosenberg, Pereyra, Florencia, Rachel Allgaier, Trocha, Alicja, Todd M. Allen, Moza, Beenu, Allen, TM, Eric J. Sundberg, Mui, SK, Bruce D. Walker, Sundberg, EJ, Katie L. Williams, Gandhi, RT, Yu, Xu G, Rachel Allen, Daniel G. Kavanagh, Beenu Moza, Sundberg, Eric J, Alicja Trocha, Gandhi, Rajesh T, Moza, B, Margaret Feeney, Xu G. Yu, Rosenberg, ES, Mui, Stanley K, Mathias Lichterfeld, Florencia Pereyra, Walker, BD, Rajesh T. Gandhi, Sivamurthy, Rohini, Kavanagh, DG, Trocha, A, Lichterfeld, Mathias, Allen, R, Lichterfeld, M, Williams, Katie L, Allen, Rachel, ToshiYuki Miura, Miura, ToshiYuki, Walker, Bruce D, Miura, T, Yu, XG, Kavanagh, Daniel G, Altfeld, Marcus   +56 more
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Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Models for Natural Killer Cell Repertoire Formation

Clinical and Developmental Immunology, 2003
Natural killer (NK) cells lyse only cells that do not express sufficient levels of self class I MHC molecules. Inhibition of lysis is mediated by inhibitory receptors expressed by NK cells, such as the murine Ly49 receptors, that bind to MHC class I ...
Mali Salmon-Divon, Petter Höglund, Ramit Mehr   +2 more
doaj   +1 more source

Quantifying the protection of activating and inhibiting NK cell receptors during infection with a CMV-like virus

Frontiers in Immunology, 2014
The responsiveness of natural killer (NK) cells is controlled by balancing signals from activating and inhibitory receptors. The most important ligands of inhibitory NK cell receptors are the highly polymorphic major histocompatibility complex (MHC ...
Rob J De Boer, Can eKesmir, Paola eCarrillo-Bustamante   +2 more
doaj   +1 more source

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

A novel soluble immune-type receptor (SITR) in teleost fish: carp SITR is involved in the nitric oxide-mediated response to a protozoan parasite [PDF]

, 2011
Background- The innate immune system relies upon a wide range of germ-line encoded receptors including a large number of immunoglobulin superfamily (IgSF) receptors.
Wiegertjes Geert F., Geert Raes, Schijns Virgil E. J. C., Ghassabeh, G.H., Huub F. J. Savelkoul, Savelkoul, H.F.J., Geert F Wiegertjes, Savelkoul Huub F. J., Virgil E J C Schijns, Ghassabeh Gholamreza H., Gholamreza H. Ghassabeh, Maria J. S. L. Pontes, Wiegertjes, G.F., Carla M S Ribeiro, Schijns, V.E.J.C., Steve Bird, Raes, G., Maria J S L Pontes, Huub F J Savelkoul, Virgil E. J. C. Schijns, Raes Geert, Ribeiro, C.M.S., Bird Steve, Gholamreza H Ghassabeh, Carla M. S. Ribeiro, Pontes, M.J.S.L., Ribeiro Carla M. S., Pontes Maria J. S. L., Geert F. Wiegertjes   +28 more
core   +2 more sources

Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.

PLoS Biology, 2016
It has recently been appreciated that NK cells exhibit many features reminiscent of adaptive immune cells. Considerable heterogeneity exists with respect to the ligand specificity of individual NK cells and as such, a subset of NK cells can respond ...
Jacquelyn Freund, Rebecca M May, Enjun Yang, Hongchuan Li, Matthew McCullen, Bin Zhang, Todd Lenvik, Frank Cichocki, Stephen K Anderson, Taku Kambayashi   +9 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Recombinant glycine receptors: stoichiometry and kinetics [PDF]

, 2009
Glycine receptors (GlyR) are anion-permeable channels that belong to the pentameric ligand-gated ion channel family. Different GlyR subtypes are known. The main synaptic form is thought to be α1β heteropentamers which mediate fast synaptic inhibition in ...
Krashia, P.
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