Results 11 to 20 of about 7,554 (201)

Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding [PDF]

International Journal of Molecular Sciences, 2020
Immune checkpoints are crucial in the maintenance of antitumor immune responses. The activation or blockade of immune checkpoints is dependent on the interactions between receptors and ligands; such interactions can provide inhibitory or stimulatory signals, including the enhancement or suppression of T-cell proliferation, differentiation, and/or ...
Marta Spodzieja, Katarzyna Kuncewicz, Adam Sieradzan, Agnieszka Karczyńska, Justyna Iwaszkiewicz, Valérie Cesson, Katarzyna Węgrzyn, Igor Zhukov, Martyna Maszota-Zieleniak, Olivier Michielin, Daniel E. Speiser, Vincent Zoete, Laurent Derré, Sylwia Rodziewicz-Motowidło   +13 more
openaire   +5 more sources

Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa [PDF]

Cell Reports, 2022
Summary: The Btla inhibitory receptor limits innate and adaptive immune responses, both preventing the development of autoimmune disease and restraining anti-viral and anti-tumor responses.
Caroline Stienne, Richard Virgen-Slane, Lisa Elmén, Marisol Veny, Sarah Huang, Jennifer Nguyen, Elizabeth Chappell, Mary Olivia Balmert, Jr-Wen Shui, Michelle A. Hurchla, Mitchell Kronenberg, Scott N. Peterson, Kenneth M. Murphy, Carl F. Ware, John R. Šedý   +14 more
doaj   +2 more sources

The Methylation in B7-H4 and BTLA Genes are Associated with the Risk of Pulmonary Tuberculosis

ImmunoTargets and Therapy, 2023
Xue-Qian Cai,1,* Qian Huang,2,* Tian-Ping Zhang3 1Department of Respiratory and Critical Care Medicine, Anhui Chest Hospital, Hefei, People’s Republic of China; 2Department of Public Health, Medical Department, Qinghai University, Xining, People ...
Cai XQ, Huang Q, Zhang TP
doaj   +1 more source

BTLA Expression in CLL: Epigenetic Regulation and Impact on CLL B Cell Proliferation and Ability to IL-4 Production

Cells, 2021
In our previous study, while chronic lymphocytic leukemia (CLL) cases showed higher levels of B and T lymphocyte attenuator (BTLA) mRNA compared to controls, lower BTLA protein expression was observed in cases compared to controls.
Lidia Karabon, Anna Andrzejczak, Lidia Ciszak, Anna Tomkiewicz, Aleksandra Szteblich, Agnieszka Bojarska-Junak, Jacek Roliński, Dariusz Wołowiec, Tomasz Wróbel, Agata Kosmaczewska   +9 more
doaj   +2 more sources

The Co-inhibitor BTLA Is Functional in ANCA-Associated Vasculitis and Suppresses Th17 Cells

Frontiers in Immunology, 2019
Objectives: The activation and inhibition of T-cells has been well-studied under physiological conditions. Co-inhibition is an important mechanism to keep effector T-cells in check.
Kai Werner, Sebastian Dolff, Yang Dai, Xin Ma, Alexandra Brinkhoff, Johannes Korth, Anja Gäckler, Hana Rohn, Ming Sun, Jan Willem Cohen Tervaert, Pieter van Paassen, Andreas Kribben, Oliver Witzke, Benjamin Wilde   +13 more
doaj   +2 more sources

BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection [PDF]

Frontiers in Immunology, 2019
B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells.
Xueping Yu, Xueping Yu, Yijuan Zheng, Richeng Mao, Zhijun Su, Jiming Zhang   +5 more
doaj   +2 more sources

Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses. [PDF]

PLoS ONE, 2017
Antibody based immune-checkpoint blockade therapy is a major breakthrough in oncology, leading to clinical benefit for cancer patients. Among the growing family of inhibitory receptors, the B and T lymphocyte attenuator (BTLA), which interacts with ...
Marta Spodzieja, Sławomir Lach, Justyna Iwaszkiewicz, Valérie Cesson, Katarzyna Kalejta, Daniel Olive, Olivier Michielin, Daniel E Speiser, Vincent Zoete, Laurent Derré, Sylwia Rodziewicz-Motowidło   +10 more
doaj   +2 more sources

BTLA and PD-1 signals attenuate TCR-mediated transcriptomic changes

iScience
Summary: T cell co-inhibitory immune checkpoints, such as PD-1 or BTLA, are bona fide targets in cancer therapy. We used a human T cell reporter line to measure transcriptomic changes mediated by PD-1- and BTLA-induced signaling.
Muhammad Zainul Arifin, Judith Leitner, Donagh Egan, Petra Waidhofer-Söllner, Walter Kolch, Vadim Zhernovkov, Peter Steinberger   +6 more
doaj   +2 more sources

Abnormal Expression of BTLA and CTLA-4 Immune Checkpoint Molecules in Chronic Lymphocytic Leukemia Patients

Journal of Immunology Research, 2020
Chronic lymphocytic leukemia (CLL) is characterized by the peripheral accumulation of neoplastic B cells and is frequently complicated by the systemic immunosuppression associated with an impairment in B and T lymphocyte activation.
L. Karabon, A. Partyka, L. Ciszak, E. Pawlak-Adamska, A. Tomkiewicz, A. Bojarska-Junak, J. Roliński, D. Wołowiec, T. Wrobel, I. Frydecka, A. Kosmaczewska   +10 more
doaj   +2 more sources

BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4+ T-cell exhaustion

Nature Communications
B- and T-lymphocyte attenuator (BTLA) levels are increased in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). This condition is characterized by susceptibility to infection and T-cell immune exhaustion. However, whether
Xueping Yu, Feifei Yang, Zhongliang Shen, Yao Zhang, Jian Sun, Chao Qiu, Yijuan Zheng, Weidong Zhao, Songhua Yuan, Dawu Zeng, Shenyan Zhang, Jianfei Long, Mengqi Zhu, Xueyun Zhang, Jingwen Wu, Zhenxuan Ma, Haoxiang Zhu, Milong Su, Jianqing Xu, Bin Li, Richeng Mao, Zhijun Su, Jiming Zhang   +22 more
doaj   +2 more sources