Results 21 to 30 of about 7,554 (201)

Internal regulation between constitutively expressed T cell co-inhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants [PDF]

Open Biology
Immunologic self-tolerance involves signals from co-inhibitory receptors. Several T cell co-inhibitors, including PD-1, are expressed upon activation, whereas CD5 and BTLA are expressed constitutively. The relationship between constitutively expressed co-
Adeolu O. Adegoke, Govindarajan Thangavelu, Ting-Fang Chou, Marcos I. Petersen, Kiyokazu Kakugawa, Julia F. May, Kevin Joannou, Qingyang Wang, Kristofor K. Ellestad, Louis Boon, Peter A. Bretscher, Hilde Cheroutre, Mitchell Kronenberg, Troy A. Baldwin, Colin C. Anderson   +14 more
doaj   +2 more sources

Picture naming: Stereoelectroencephalography and connectivity insights. [PDF]

Epilepsia
Abstract Objective This study investigates the neural substrates of picture naming (PN) using stereoelectroencephalographic (SEEG) stimulations and evaluates the contribution of white matter (WM) fascicles related to the basal temporal language area (BTLA) to the broader functional PN network.
Mezjan I, Rech F, Aron O, Maillard L, Colnat-Coulbois S.   +4 more
europepmc   +2 more sources

High BTLA Expression Likely Contributes to Contraction of the Regulatory T Cell Subset in Lupus Disease

Frontiers in Immunology, 2021
B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor that is expressed by lymphoid cells and regulates the immune response. Consistent with an inhibitory role for BTLA, the disease is exacerbated in BTLA-deficient lupus mice.
Lucie Aubergeon, Matthieu Sawaf, Renaud Felten, Renaud Felten, Jacques-Eric Gottenberg, Jacques-Eric Gottenberg, Hélène Dumortier, Fanny Monneaux   +7 more
doaj   +1 more source

BTLA-derived peptides as inhibitors of BTLA/HVEM complex formation – design, synthesis and biological evaluation

Biomedicine & Pharmacotherapy, 2023
Immune checkpoints can be divided into co-stimulatory and co-inhibitory molecules that regulate the activation and effector functions of T cells. The co-inhibitory pathways mediated by ICPs are used by cancer cells to escape from immune surveillance, and therefore the blockade of these receptor/ligand interactions is one of the strategies used in the ...
Katarzyna Kuncewicz, Magdalena Bojko, Claire Battin, Agnieszka Karczyńska, Adam Sieradzan, Emilia Sikorska, Katarzyna Węgrzyn, Karolina Wojciechowicz, Anna Wardowska, Peter Steinberger, Sylwia Rodziewicz-Motowidło, Marta Spodzieja   +11 more
openaire   +2 more sources

Friend or Foe: Prognostic and Immunotherapy Roles of BTLA in Colorectal Cancer

Frontiers in Molecular Biosciences, 2020
BackgroundB and T lymphocyte attenuator (BTLA) is a co-signaling protein belonging to the CD28 immunoglobulin superfamily. However, the role of BTLA in prognosis and immunotherapy of colorectal cancer (CRC) remains unclear.MethodsWe evaluated the ...
Jingjing Song, Jingjing Song, Lihui Wu, Lihui Wu   +3 more
doaj   +1 more source

Exploration of the Prognostic and Immunotherapeutic Value of B and T Lymphocyte Attenuator in Skin Cutaneous Melanoma

Frontiers in Oncology, 2021
B and T lymphocyte attenuator (BTLA) is a newly identified immune checkpoint molecular belonging to the CD28 immunoglobulin superfamily. However, the expression and clinical value of BTLA in skin cutaneous melanoma (SKCM) has not been widely ...
Xubin Dong, Jingjing Song, Buran Chen, Yufeng Qi, Wenjie Jiang, Huihui Li, Danni Zheng, Yinghao Wang, Xiaohua Zhang, Haiguang Liu   +9 more
doaj   +1 more source

BTLA-Expressing Dendritic Cells in Patients With Tuberculosis Exhibit Reduced Production of IL-12/IFN-α and Increased Production of IL-4 and TGF-β, Favoring Th2 and Foxp3+ Treg Polarization

Frontiers in Immunology, 2020
Little is known about how tuberculosis (TB) impairs dendritic cell (DC) function and anti-TB immune responses. We previously showed that the B and T lymphocyte attenuator (BTLA), an immune inhibitory receptor, is involved in TB pathogenesis.
Jun-Ai Zhang, Jun-Ai Zhang, Yuan-Bin Lu, Yuan-Bin Lu, Wan-Dang Wang, Wan-Dang Wang, Gan-Bin Liu, Chen Chen, Chen Chen, Ling Shen, Hou-Long Luo, Hou-Long Luo, Huan Xu, Huan Xu, Ying Peng, Ying Peng, Hong Luo, Hong Luo, Gui-Xian Huang, Gui-Xian Huang, Du-Du Wu, Bi-Ying Zheng, Lai-Long Yi, Zheng W. Chen, Jun-Fa Xu, Jun-Fa Xu   +25 more
doaj   +1 more source

BTLA as a biomarker and mediator of sepsis-induced immunosuppression [PDF]

Critical Care, 2013
Recent research indicates that T-lymphocyte dysfunction may contribute to sepsis-associated morbidity and mortality. B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor expressed by T lymphocytes and B lymphocytes that is important in regulating lymphocyte activation during inflammation and infection.
Sherwood, Edward R, Hotchkiss, Richard S
openaire   +2 more sources

BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination [PDF]

, 2010
The function of antigen-specific CD8+ T cells, which may protect against both infectious and malignant diseases, can be impaired by ligation of their inhibitory receptors, which include CTL-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1).
Camilla Jandus, Michielin, O., Jandus, C., Jandus, Camilla, Derré, L., Derré, Laurent, Pastor, Sonia, Michielin, Olivier, Daniel Olive, Laurent Derré, Olive, D., Daniel E. Speiser, Rivals, Jean-Paul, Rivals, J.P., Pastor, S., Romero, P., Speiser, D.E., Sonia Pastor, Pedro Romero, Speiser, Daniel E, Jean-Paul Rivals, Olivier Michielin, Donata Rimoldi, Rimoldi, Donata, Olive, Daniel, Romero, Pedro, Rimoldi, D.   +26 more
core   +2 more sources

Variation in the gene encoding the co-inhibitory molecule BTLA is associated with survival in patients treated for clear cell renal carcinoma – results of a prospective cohort study

Archives of Medical Science, 2021
Introduction The successful introduction of immune checkpoint blockade approaches to renal-cell carcinoma (RCC) treatment indicates the importance of molecules regulating the T cell response to RCC risk and progression.
Krzysztof Tupikowski, Anna Partyka, Edyta A. Pawlak, Kuba Ptaszkowski, Romuald Zdrojowy, Irena Frydecka, Agnieszka Hałoń, Lidia Karabon   +7 more
doaj   +1 more source