Results 1 to 10 of about 3,011 (240)

The Role of B and T Lymphocyte Attenuator in Respiratory System Diseases [PDF]

Frontiers in Immunology, 2021
B and T lymphocyte attenuator (BTLA), an immunomodulatory molecule widely expressed on the surface of immune cells, can influence various signaling pathways and negatively regulate the activation and proliferation of immune cells by binding to its ligand
Zheng Zheng
exaly   +7 more sources

A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis [PDF]

Clinical and Developmental Immunology, 2011
Inhibitory coreceptors are thought to play important roles in maintaining immunological homeostasis, and a defect in the negative signals from inhibitory coreceptors may lead to the development of autoimmune diseases. We have recently identified B and T
Mie Oki, Norihiko Watanabe, Takayoshi Owada, Yoshihiro Oya, Kei Ikeda, Yasushi Saito, Ryutaro Matsumura, Yohei Seto, Itsuo Iwamoto, Hiroshi Nakajima   +9 more
doaj   +7 more sources

Exploration of the Prognostic and Immunotherapeutic Value of B and T Lymphocyte Attenuator in Skin Cutaneous Melanoma [PDF]

Frontiers in Oncology, 2021
B and T lymphocyte attenuator (BTLA) is a newly identified immune checkpoint molecular belonging to the CD28 immunoglobulin superfamily. However, the expression and clinical value of BTLA in skin cutaneous melanoma (SKCM) has not been widely ...
Xiaohua Zhang, Xubin Dong, Jingjing Song   +2 more
exaly   +7 more sources

Targeting B and T Lymphocyte Attenuator Regulates Lupus Disease Development in NZB/W Mice [PDF]

ImmunoTargets and Therapy
Léa Gherardi,* Lucie Aubergeon,* Mélanie Sayah, Jean-Daniel Fauny, Hélène Dumortier, Fanny Monneaux CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg, 67084, France&ast ...
Gherardi L, Aubergeon L, Sayah M, Fauny JD, Dumortier H, Monneaux F   +5 more
doaj   +7 more sources

Soluble B and T Lymphocyte Attenuator Correlates to Disease Severity in Sepsis and High Levels Are Associated with an Increased Risk of Mortality [PDF]

PLoS ONE, 2017
B- and T-lymphocyte Attenuator (BTLA), Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Death 1 (PD-1) are co-inhibitory receptors that regulate T cell activation.
Anna Lange, Jonas Sundén-Cullberg, Anders Magnuson   +2 more
exaly   +4 more sources

B- and T-Lymphocyte Attenuator Expression on Regulatory T-Cells in Patients with Severe Sepsis [PDF]

Chinese Medical Journal, 2018
Wei Yuan, Le An
exaly   +6 more sources

B and T lymphocyte attenuator tempers early infection immunity. [PDF]

J Immunol, 2009
Abstract Coinhibitory pathways are thought to act in later stages of an adaptive immune response, but whether coinhibition contributes to early innate immunity is unclear. We show that engagement of the newly discovered coinhibitory receptor B and T lymphocyte attenuator (BTLA) by herpesvirus entry mediator (HVEM) is critical for ...
Sun Y, Brown NK, Ruddy MJ, Miller ML, Lee Y, Wang Y, Murphy KM, Pfeffer K, Chen L, Kaye J, Fu YX.   +10 more
europepmc   +17 more sources

Sustained elevation of soluble B- and T- lymphocyte attenuator predicts long-term mortality in patients with bacteremia and sepsis. [PDF]

PLoS ONE, 2022
Soluble B and T lymphocyte attenuator (sBTLA) has been shown to be associated with severity and outcome, in critically ill septic patients. We aimed to assess the dynamic expression of sBTLA, as a prognostic biomarker of long-term mortality in patients ...
Anna Lange, Sara Cajander, Anders Magnuson, Kristoffer Strålin, Olof Hultgren   +4 more
doaj   +3 more sources

B and T lymphocyte attenuator regulates T cell survival in the lung. [PDF]

J Immunol, 2008
Abstract The initiation, intensity, and duration of T cell-directed inflammatory responses are dependent upon the coordination of both activating and inhibitory signals mediated by specific receptors on the T lymphocyte. The recently described receptor, B and T lymphocyte attenuator (BTLA), has been demonstrated to have an important ...
Deppong C, Degnan JM, Murphy TL, Murphy KM, Green JM.   +4 more
europepmc   +4 more sources

B and T lymphocyte attenuator expression in mature B cell lymphomas [PDF]

Journal of Hematopathology, 2012
B and T lymphocyte attenuator (BTLA) is a lymphocyte inhibitory receptor mainly expressed on several subsets of T and B lymphocytes. In the current retrospective study, BTLA expression is examined for the first time on formalin fixed and paraffin embedded (FFPE) tissue sections of mature B cell non-Hodgkin's lymphomas (253 cases), using a newly ...
Philippe Trougouboff, Hila Kreizman Shefer   +1 more
exaly   +2 more sources