Results 31 to 40 of about 3,011 (240)
Roles of BTLA in Immunity and Immune Disorders
Frontiers in Immunology, 2021 B and T lymphocyte attenuator (BTLA) is one of the most important cosignaling molecules. It belongs to the CD28 superfamily and is similar to programmed cell death-1 (PD-1) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) in terms of its ...
Zhaochen Ning +4 more
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A combination of the activation marker CD86 and the immune checkpoint marker B and T lymphocyte attenuator (BTLA) indicates a putative permissive activation state of B cell subtypes in healthy blood donors independent of age and sex. [PDF]
BMC Immunol, 2020 BACKGROUND: The use of anti-B cell based therapies in immune-mediated diseases targeting general B cell markers or molecules important for B cell function has increased the clinical needs of monitoring B cell subpopulations.RESULTS: We analyzed the ...
Axelsson S +5 more
europepmc +2 more sources
Clinical Insights Into Novel Immune Checkpoint Inhibitors
Frontiers in Pharmacology, 2021 The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1), and programmed death ligand-1 (PD-L1), has revolutionized treatment options ...
Jii Bum Lee +3 more
doaj +1 more source
Egyptian Journal of Medical Human Genetics, 2021 Background One of the crucial functions of the immune system is to prevent tumorigenesis, yet cancer occurs when malignant cells manage to evade immune surveillance via multiple strategies.
Sara M. Radwan +4 more
doaj +1 more source
PLoS ONE, 2021 The T cell expression of various co-signalling receptors from the CD28 immunoglobulin superfamily (Inducible T cell co-stimulator (ICOS), Programmed cell death 1(PD-1), cytotoxic T lymphocyte associated protein 4 (CTLA-4), B and T lymphocyte attenuator ...
Fabienne Mazerolles +1 more
doaj +2 more sources
In vitro vascularized immunocompetent patient-derived model to test cancer therapies
iScience, 2023 Summary: This work describes a patient-derived tumoroid model (PDTs) to support precision medicine in lung oncology. The use of human adipose tissue-derived microvasculature and patient-derived peripheral blood mononuclear cells (PBMCs) permits to ...
Hélène Lê +12 more
doaj +1 more source
Functional Analysis of B and T Lymphocyte Attenuator Engagement on CD4+ and CD8+ T Cells [PDF]
The Journal of Immunology, 2005 Abstract T cell activation can be profoundly altered by coinhibitory and costimulatory molecules. B and T lymphocyte attenuator (BTLA) is a recently identified inhibitory Ig superfamily cell surface protein found on lymphocytes and APC.
Carsten, Krieg +4 more
openaire +2 more sources
Soluble B7-CD28 Family Inhibitory Immune Checkpoint Proteins and Anti-Cancer Immunotherapy
Frontiers in Immunology, 2021 Co-inhibitory B7-CD28 family member proteins negatively regulate T cell responses and are extensively involved in tumor immune evasion. Blockade of classical CTLA-4 (cytotoxic T lymphocyte-associated antigen-4) and PD-1 (programmed cell death protein-1 ...
Muhammad Khan +4 more
doaj +1 more source
Ligation of B and T Lymphocyte Attenuator Prevents the Genesis of Experimental Cerebral Malaria [PDF]
The Journal of Immunology, 2007 Abstract B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory receptor that is predominantly expressed on T and B cells and dampens T cell activation. In this study, we analyzed the function of BTLA during infection with Plasmodium berghei ANKA.
Bernd, Lepenies +7 more
openaire +2 more sources
Indian Journal of Pathology and Microbiology, 2019 Background: As an immune checkpoint, upregulation of B and T lymphocyte attenuator (BTLA) contributes to T-cell exhaustion in chronic infection. However, the characteristics of BTLA on T cells of patients with pulmonary tuberculosis (PTB) are still ...
Xinghua Shen +8 more
doaj +1 more source