Results 11 to 20 of about 3,011 (240)

The Influence of B and T Lymphocyte Attenuator Genetic Variants on Susceptibility to Chronic Hepatitis B Virus Infection [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: B and T lymphocyte attenuator (BTLA) is an immune inhibitory receptor involved in the pathogenesis of chronic viral infections. Little is known about the effects of BTLA gene polymorphisms on chronic hepatitis B virus (HBV) infections ...
Jie Tang, Jiaqian Fei, Chunxia Gu, Weixia Liu, Minwei Li, Cheng Zhou   +5 more
doaj   +6 more sources

B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells [PDF]

Cardiovascular Research, 2019
The immune system is strongly involved in atherosclerosis and immune regulation generally leads to attenuated atherosclerosis. B- and T-lymphocyte attenuator (BTLA) is a novel co-receptor that negatively regulates the activation of B and T cells; however, there have been no reports of BTLA and its function in atherosclerosis or cardiovascular disease ...
Christoph J Binder, Ilze Bot, Jacob Amersfoort   +2 more
exaly   +5 more sources

Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. [PDF]

J Immunol, 2009
Abstract T cell activation and tolerance are delicately regulated by costimulatory molecules. Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator for T cell activation, its role in peripheral T cell tolerance induction in vivo has not been addressed.
Liu X, Alexiou M, Martin-Orozco N, Chung Y, Nurieva RI, Ma L, Tian Q, Kollias G, Lu S, Graf D, Dong C.   +10 more
europepmc   +7 more sources

Stimulation of Immune Checkpoint Molecule B and T-Lymphocyte Attenuator Alleviates Experimental Crescentic Glomerulonephritis. [PDF]

J Am Soc Nephrol, 2023
Significance Statement Treatment of acute, crescentic glomerulonephritis (GN) consists of unspecific and potentially toxic immunosuppression. T cells are central in the pathogenesis of GN, and various checkpoint molecules control their activation.
Diefenhardt P, Braumann M, Schömig T, Trinsch B, Sierra Gonzalez C, Becker-Gotot J, Völker LA, Ester L, Mandel AM, Hawiger D, Abdallah AT, Schermer B, Göbel H, Brinkkötter P, Kurts C, Benzing T, Brähler S.   +16 more
europepmc   +3 more sources

B and T Lymphocyte Attenuator Restricts the Protective Immune Response against Experimental Malaria [PDF]

The Journal of Immunology, 2011
Abstract The immune response against the blood stage of malaria has to be tightly regulated to allow for vigorous antiplasmodial activity while restraining potentially lethal immunopathologic damage to the host like cerebral malaria. Coinhibitory cell surface receptors are important modulators of immune activation.
Guido, Adler, Christiane, Steeg, Klaus, Pfeffer, Theresa L, Murphy, Kenneth M, Murphy, Jean, Langhorne, Thomas, Jacobs   +6 more
openaire   +3 more sources

The synergism of B and T lymphocyte attenuator (BTLA) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) attenuated acute T-cell mediated rejection and prolonged renal graft survival. [PDF]

Transl Androl Urol, 2020
Acute T-cell mediated rejection (TCMR) continues to be a major problem in the area of kidney transplantation. The B and T lymphocyte attenuator (BTLA) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) were recently found costimulatory molecules. The research aims to explore the inhibitory synergism of BTLA and CTLA-4 in TCMR.We investigated the ...
Zhang H, Wang Z, Zhang J, Zhang X, Gui Z, Sun L, Yang H, Tan R, Gu M.   +8 more
europepmc   +5 more sources

Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Müller, Werner, Frommer, Friederike, Heinen, Tobias J. A. J., Buch, Thorsten, Heinen, Tobias J A J, Anderton, Stephen M, Bettelli, Estelle, Waisman, Ari, Wunderlich, F Thomas, Mueller, Werner, Wunderlich, F. Thomas, Roers, Axel, Müller, Werner; id_orcid, Yogev, Nir, Anderton, Stephen M.   +14 more
core   +14 more sources

Pan-Cancer Landscape of B- and T-Lymphocyte Attenuator: Implications for Potential Immunotherapy Combinations. [PDF]

JCO Precis Oncol
PURPOSE Cotargetable immune pathways for available immune checkpoint inhibitors (ICIs) may mediate response and mitigate resistance. Immune profiling may provide insights into potential immunotherapy combinations and guide ongoing clinical trials.
Nishizaki D, Choi S, Pandya C, Lee S, Pabla S, DePietro P, Jensen TJ, Kurzrock R, Kato S.   +8 more
europepmc   +4 more sources

B and T Lymphocyte Attenuator Is Highly Expressed on CMV-Specific T Cells during Infection and Regulates Their Function [PDF]

The Journal of Immunology, 2010
Abstract B and T lymphocyte attenuator (BTLA), like its relative programmed cell death-1 (PD-1), is a receptor that negatively regulates murine T cell activation. However, its expression and function on human T cells is currently unknown.
Serriari, Nacer-Eddine, Gondois-Rey, Françoise, Guillaume, Yves, Remmerswaal, Ester B. M., Pastor, Sonia, Messal, Nassima, Truneh, Alemseged, Hirsch, Ivan, van Lier, René A. W., Olive, Daniel   +9 more
openaire   +3 more sources

Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells. [PDF]

J Leukoc Biol, 2010
Abstract The surface expression of BTLA and its accumulation at the immunological synapse are tightly regulated by TCR and HVEM stimulation in CD4+ T cells. BTLA, a recently cloned coreceptor expressed on lymphocytes, negatively regulates cell activation by recruiting SHP-1/SHP-2.
Owada T, Watanabe N, Oki M, Oya Y, Saito Y, Saito T, Iwamoto I, Murphy TL, Murphy KM, Nakajima H.   +9 more
europepmc   +3 more sources