Results 41 to 50 of about 3,011 (240)

BTLA-Expressing Dendritic Cells in Patients With Tuberculosis Exhibit Reduced Production of IL-12/IFN-α and Increased Production of IL-4 and TGF-β, Favoring Th2 and Foxp3+ Treg Polarization

Frontiers in Immunology, 2020
Little is known about how tuberculosis (TB) impairs dendritic cell (DC) function and anti-TB immune responses. We previously showed that the B and T lymphocyte attenuator (BTLA), an immune inhibitory receptor, is involved in TB pathogenesis.
Jun-Ai Zhang, Jun-Ai Zhang, Yuan-Bin Lu, Yuan-Bin Lu, Wan-Dang Wang, Wan-Dang Wang, Gan-Bin Liu, Chen Chen, Chen Chen, Ling Shen, Hou-Long Luo, Hou-Long Luo, Huan Xu, Huan Xu, Ying Peng, Ying Peng, Hong Luo, Hong Luo, Gui-Xian Huang, Gui-Xian Huang, Du-Du Wu, Bi-Ying Zheng, Lai-Long Yi, Zheng W. Chen, Jun-Fa Xu, Jun-Fa Xu   +25 more
doaj   +1 more source

Targeting immune checkpoints in anti-neutrophil cytoplasmic antibodies associated vasculitis: the potential therapeutic targets in the future

Frontiers in Immunology, 2023
Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) is a necrotizing vasculitis mainly involving small blood vessels. It is demonstrated that T cells are important in the pathogenesis of AAV, including regulatory T cells (Treg ...
Menglu Pan, Huanhuan Zhao, Ruimin Jin, Patrick S. C. Leung, Zongwen Shuai, Zongwen Shuai   +5 more
doaj   +1 more source

B and T Lymphocyte Attenuator Regulates B Cell Receptor Signaling by Targeting Syk and BLNK [PDF]

The Journal of Immunology, 2009
Abstract B and T lymphocyte attenuator (BTLA) functions as a negative regulator of T cell activation and proliferation. Although the role of BTLA in regulating T cell responses has been characterized, a thorough investigation into the precise molecular mechanisms involved in BTLA-mediated lymphocyte attenuation and, more specifically,
Andrew C, Vendel, Jill, Calemine-Fenaux, Anita, Izrael-Tomasevic, Vandana, Chauhan, David, Arnott, Dan L, Eaton   +5 more
openaire   +2 more sources

The function and origin of the CD4+ T cell in the classical Hodgkin lymphoma microenvironment [PDF]

, 2012
PhDClassical Hodgkin lymphoma (CHL) is a germinal centre B cell malignancy where the bulk of the tumour comprises a non-clonal immune infiltrate enriched for CD4+ T cells.
Greaves, Paul
core   +4 more sources

Mixing signals: Molecular turn ons and turn offs for innate γδ Τ cells

Frontiers in Immunology, 2014
Lymphocytes of the gamma delta (γδ) T cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors a large proportion respond as innate effectors. γδ T cells are poised to combat infection by responding rapidly
Vasileios eBekiaris, Vasileios eBekiaris, John S Šedý, Carl F Ware   +3 more
doaj   +1 more source

Abnormal Expression of BTLA and CTLA-4 Immune Checkpoint Molecules in Chronic Lymphocytic Leukemia Patients

Journal of Immunology Research, 2020
Chronic lymphocytic leukemia (CLL) is characterized by the peripheral accumulation of neoplastic B cells and is frequently complicated by the systemic immunosuppression associated with an impairment in B and T lymphocyte activation.
L. Karabon, A. Partyka, L. Ciszak, E. Pawlak-Adamska, A. Tomkiewicz, A. Bojarska-Junak, J. Roliński, D. Wołowiec, T. Wrobel, I. Frydecka, A. Kosmaczewska   +10 more
doaj   +1 more source

BTLA Expression and Function Are Impaired on SLE B Cells

Frontiers in Immunology, 2021
B- and T-lymphocyte attenuator (BTLA/CD272) is an inhibitory checkpoint molecule expressed on T and B cells. Prior studies reported defective function of BTLA by T cells in patients with systemic lupus erythematosus (SLE), whereas nothing is known about ...
Annika Wiedemann, Annika Wiedemann, Marie Lettau, Marie Lettau, Sarah Y. Weißenberg, Sarah Y. Weißenberg, Ana-Luisa Stefanski, Ana-Luisa Stefanski, Eva-Vanessa Schrezenmeier, Eva-Vanessa Schrezenmeier, Eva-Vanessa Schrezenmeier, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Karin Reiter, Karin Reiter, Tobias Alexander, Tobias Alexander, Falk Hiepe, Falk Hiepe, Andreia C. Lino, Andreia C. Lino, Thomas Dörner, Thomas Dörner   +24 more
doaj   +1 more source

B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation. [PDF]

, 2012
Allogeneic stem cell transplantation (allo-SCT) can cure hematological malignancies by inducing alloreactive T cell responses targeting minor histocompatibility antigens (MiHA) expressed on malignant cells.
Maas, F., Fredrix, H., Norde, W.J., Hobo, W., Falkenburg, J.H.F., Schaap, N., Dolstra, H., Olive, D., Korman, A.J., Voort, R. van der, Schellens, K., Hobo, W.A., Schaap, N.P.   +12 more
core   +1 more source

The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota

Frontiers in Immunology, 2022
The herpes virus entry mediator (HVEM) is an immune checkpoint molecule regulating immune response, but its role in tissue repair remains unclear. Here, we reported that HVEM deficiency aggravated hepatobiliary damage and compromised liver repair after 3,
Yanbo Kou, Xingping Zheng, Liyuan Meng, Mengnan Liu, Shihong Xu, Qiyue Jing, Shenghan Zhang, Hanying Wang, Jinzhi Han, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang   +11 more
doaj   +1 more source

B and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation [PDF]

Iranian Journal of Immunology, 2016
Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear.
Yongan Liu, Wei Nie, Yu Jin, Anshan Zhuo, Yuansheng Zang, Qingyu Xiu   +5 more
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