BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection [PDF]
Frontiers in Immunology, 2019 B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells.
Xueping Yu +5 more
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B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients. [PDF]
Crit Care, 2013 Abstract Introduction Sepsis is a deadly inflammatory condition that often leads to an immune suppressed state; however, the events leading to this state remain poorly understood. B and T lymphocyte attenuator (BTLA) is an immune-regulatory receptor shown to effectively inhibit CD4+ T-cell function ...
Shubin NJ +4 more
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Association between B and T lymphocyte attenuator/herpes virus entry mediator immunoregulatory axis and outcome prediction in a mixed critically ill population [PDF]
Scientific ReportsB and T lymphocyte attenuator (BTLA) and herpes virus entry mediator (HVEM) are emerging immune checkpoint molecules implicated in immune dysregulation during critical illness.
Stelios Kokkoris +10 more
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Role of B and T Lymphocyte Attenuator in Renal Transplant Recipients with Biopsy-Proven Acute Rejection [PDF]
Medical Science Monitor, 2018 Chunchun Zhao +2 more
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cTfh Cell Activation and Changes in BTLA and LAG-3 Expression Differentially Associate With Poor Pregnancy Outcome in Plasmodium falciparum Placental Malaria [PDF]
Journal of Immunology ResearchContinuous exposure to antigens drives the activation of circulating T follicular helper (cTfh) cells, promoting high-affinity antibody production. However, sustained stimulation may impair their function through the upregulation of immunoregulatory ...
Bernard Marie Zambo Bitye +7 more
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Selective blockade of herpesvirus entry mediator-B and T lymphocyte attenuator pathway ameliorates acute graft-versus-host reaction. [PDF]
J Immunol, 2012 [EN] The cosignaling network mediated by the herpesvirus entry mediator (HVEM; TNFRSF14) functions as a dual directional system that involves proinflammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein D for ...
del Rio ML +6 more
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A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator [PDF]
Journal of Biological Chemistry, 2017 Carl Ware +2 more
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Decreased B and T lymphocyte attenuator in Behcet's disease may trigger abnormal Th17 and Th1 immune responses. [PDF]
Sci Rep, 2016 Behcet's disease (BD) is a chronic, systemic and recurrent inflammatory disease associated with hyperactive Th17 and Th1 immune responses. Recent studies have shown that B and T lymphocyte attenuator (BTLA) negatively regulates the immune response.
Ye Z +5 more
europepmc +2 more sources
Zhongguo linchuang yanjiu, 2023 Pancreatic cancer is one of the common malignant tumors of digestive tract and is difficult to diagnose because it is characterized by insidious onset and asymptomatic early-stage.
XIE Wenhao +4 more
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