Results 51 to 60 of about 3,011 (240)

CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA. [PDF]

PLoS ONE, 2013
Defining the molecular interactions required to program activated CD8 T cells to survive and become memory cells may allow us to understand how to augment anti-viral immunity.
Rachel Flynn, Tarun Hutchinson, Kenneth M Murphy, Carl F Ware, Michael Croft, Shahram Salek-Ardakani   +5 more
doaj   +1 more source

The role of the B- and T-lymphocyte attenuator (BTLA) in T cell activation

, 2014
Die T-Zell-Aktivierung ist ein komplexer Prozess an dem viele Rezeptoren und Liganden beteiligt sind. Eine wichtige Aufgabe in diesem Prozess haben, neben dem antigenspezifischen Signal, die so genannten Kosignale.
Wildom, Bernhard
core   +2 more sources

The Features of Checkpoint Receptor—Ligand Interaction in Cancer and the Therapeutic Effectiveness of Their Inhibition

Biomedicines, 2022
To date, certain problems have been identified in cancer immunotherapy using the inhibition of immune checkpoints (ICs). Despite the excellent effect of cancer therapy in some cases when blocking the PD-L1 (programmed death-ligand 1) ligand and the ...
Anna Kuzevanova, Natalya Apanovich, Danzan Mansorunov, Alexandra Korotaeva, Alexander Karpukhin   +4 more
doaj   +1 more source

Immune Checkpoint Protein Expression Defines the Prognosis of Advanced Thyroid Carcinoma

Frontiers in Endocrinology, 2022
BackgroundPatients with advanced thyroid carcinoma (TC), such as anaplastic thyroid carcinoma (ATC), poorly differentiated thyroid carcinoma (PDTC), and locally advanced papillary thyroid carcinoma (PTC), have poor prognoses and require novel treatments.
Yi Luo, Yi Luo, Yi-Chen Yang, Yi-Chen Yang, Cen-Kai Shen, Cen-Kai Shen, Ben Ma, Ben Ma, Wei-Bo Xu, Wei-Bo Xu, Qi-Feng Wang, Qi-Feng Wang, Yan Zhang, Yan Zhang, Tian Liao, Tian Liao, Wen-Jun Wei, Wen-Jun Wei, Yu Wang, Yu Wang   +19 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The Effect of Bicalutamide on Suppressing Inhibitory Immune Checkpoints in Mature Dendritic Cells: A Novel Approach in Prostate Cancer Immunotherapy [PDF]

مجله علوم پزشکی صدرا
Introduction: Bicalutamide, an antiandrogen agent used in prostate cancer treatment, has been shown to influence immune cells and alter the immune response within the tumor microenvironment.
Niloufar Sadat Nourbakhsh, Behzad Baradaran, Sirous Naeimi, Mehdi Moghanibashi   +3 more
doaj   +1 more source

Structural Determinants of Herpesvirus Entry Mediator Recognition by Murine B and T Lymphocyte Attenuator [PDF]

The Journal of Immunology, 2008
Abstract The B and T lymphocyte attenuator (BTLA) appears to act as a negative regulator of T cell activation and growth. BTLA specifically interacts with herpesvirus entry mediator (HVEM), a member of the TNFR family. Herein, we have undertaken surface plasmon resonance studies to quantitatively assess BTLA and HVEM ectodomain ...
Christopher A, Nelson, Marcel D, Fremont, John R, Sedy, Paula S, Norris, Carl F, Ware, Kenneth M, Murphy, Daved H, Fremont   +6 more
openaire   +2 more sources

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses. [PDF]

PLoS ONE, 2017
Antibody based immune-checkpoint blockade therapy is a major breakthrough in oncology, leading to clinical benefit for cancer patients. Among the growing family of inhibitory receptors, the B and T lymphocyte attenuator (BTLA), which interacts with ...
Marta Spodzieja, Sławomir Lach, Justyna Iwaszkiewicz, Valérie Cesson, Katarzyna Kalejta, Daniel Olive, Olivier Michielin, Daniel E Speiser, Vincent Zoete, Laurent Derré, Sylwia Rodziewicz-Motowidło   +10 more
doaj   +1 more source