Results 271 to 280 of about 7,192,603 (344)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Nrf2-Keap1 Pathway and NLRP3 Inflammasome in Parkinson's Disease: Mechanistic Crosstalk and Therapeutic Implications. [PDF]

Mol Neurobiol
Jain R, Vora L, Nathiya D, Khatri DK.
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

The Role and Therapeutic Potential of the cGAS-STING Signaling Pathway in Alzheimer's Disease. [PDF]

Brain Behav
Li X, Gao W, Ye Q, Li H.
europepmc   +1 more source

Changes in tibialis anterior muscle activity following tibial nerve block in adults with spastic equinovarus foot: an observational pilot study. [PDF]

J Rehabil Med
Picelli A, Filippetti M, Pontillo A, Dimitrova E, Valè N, Di Censo R, Smania N, Bertucco M.   +7 more
europepmc   +1 more source

Implant design may influence knee flexor activation patterns during stair ascent and descent. [PDF]

Bone Joint Res
Nelson-Tranum AK, Ford MC, Hou N, Powell DW, Holland CT, Richey PA, Mihalko WM.   +6 more
europepmc   +1 more source

Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling. [PDF]

Gut
De Luca R, Arrè V, Nardone S, Incerpi S, Giannelli G, Trivedi P, Anastasiadou E, Negro R.   +7 more
europepmc   +1 more source