Results 281 to 290 of about 7,259,671 (332)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRPC3 and TRPC6: Multimodal Cation-Conducting Channels Regulating Cardiovascular Contractility and Remodeling. [PDF]

Cells
Numaga-Tomita T, Nishida M.
europepmc   +1 more source

Validator-Certified Resolution of Gravitational Reversal via Spectral-Motivic Geometry, Entropy Threshold Activation, and Homological Sealing: A Modular Framework for Analytic, Computational, and Instructional Replication

Forrest M. Anderson, Forrest
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Lower limb muscle activation and biomechanics during single-leg hopping in different directions. [PDF]

Front Sports Act Living
Gu Y, Su W, Malik N, Nguyen T, Jordan A, Herda T, Song Y.   +6 more
europepmc   +1 more source

M-Ras Distinct Activation Scenarios: A Mechanistic Outlook and Targeting

Xu, Liang
openalex   +1 more source

Improving Clinical Patient Activation and Strengthening Health Outcomes: Findings from a Quasi-Experimental Study. [PDF]

J Clin Med
Alsaad SM, Almalki MF, Alotaibi MA, Alaraik EF, AlSaif HI, Alrasheed AA, Kerari A, Bahari G.   +7 more
europepmc   +1 more source

Additional file 13 of Fibroblast activation protein (FAP)-mediated promotion of metastasis via the FN1-TGFβ axis and immune suppression in aggressive thyroid cancer

Udinotti, Mario, Siebolts, Udo, Bauer, Marcus, Vaxevanis, Christoforos, Asiminas, Antonios, Lorenz, Kerstin, Dierks, Christine, Wickenhauser, Claudia, Seliger, Barbara   +8 more
openalex   +1 more source