Results 51 to 60 of about 3,121,584 (269)
Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice
Nature CommunicationsDe novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency, with impaired ...
Claire Soudais +17 more
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Proceedings of the National Academy of Sciences, 1919 Adsorption of Gases by Charcoal—Heat Effect.—The first part of this paper comprises a study of the heat effect on the adsorption of hydrogen and nitrogen by charcoal, and is a continuation of the work of Dr. Harvey B. Lemon1 in which air was used. The charcoal is heated for periods varying from one hour to twenty hours at temperatures from 400° C.
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An activity description language for activity recognition [PDF]
2017 International Conference on Internet of Things, Embedded Systems and Communications (IINTEC), 2017 Activity recognition aims at recognizing and understanding the movements, actions, and objectives of mobile objects. These objects can be humans, animals, or simple artefacts. Many important and critical applications such as surveillance or health care require some form of (human) activity recognition.
Sarray, Ines +4 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Actively Seeking Activating Sequences [PDF]
Cell, 2004 I thank R. Brent, I. Cartwright, L. Keegan, Z. Liu, M. Ptashne, and M. Xu for comments. I apologize that the page limit did not permit citation of all relevant work. This work was supported in part by the AHA and the NSF.
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Promotion of physical activity guidelines and behavior change
Journal of Physical Fitness and Sports Medicine, 2015 Physical activity guidelines have been published by governments to increase physical activity at a national level. Such guidelines commonly include behavior change techniques.
Kazuhiro Harada, Yoshio Nakamura
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source