Results 61 to 70 of about 3,121,584 (269)

Characterization of PM₁₀ Sampled on the Top of a Former Mining Tower by the High-Volume Wind Direction-Dependent Sampler Using INNA

Atmosphere, 2020
The PM10 concentrations in the studied region (Ostravsko-karvinská agglomeration, Czech Republic) exceed air pollution limit values in the long-term and pose a significant problem for human health, quality of life and the environment.
Irena Pavlíková, Daniel Hladký, Oldřich Motyka, Konstantin N. Vergel, Ludmila P. Strelkova, Margarita S. Shvetsova   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Neuropilin-1 Acts as a Receptor for Complement Split Products

Frontiers in Immunology, 2019
Complement split products (CSPs), such as the fragments C4d and C3d, which are generated as a consequence of complement regulatory processes, are established markers for disease activity in autoimmunity or antibody-mediated graft rejection.
Claire Battin, Annika De Sousa Linhares, Wolfgang Paster, Wolfgang Paster, David E. Isenman, Markus Wahrmann, Judith Leitner, Gerhard J. Zlabinger, Peter Steinberger, Johannes Hofer   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Biological control of Colletotrichum panacicola on Panax ginseng by Bacillus subtilis HK-CSM-1

Journal of Ginseng Research, 2014
Background: Biological control of plant pathogens using benign or beneficial microorganisms as antagonistic agents is currently considered to be an important component of integrated pest management in agricultural crops.
Hojin Ryu, Hoon Park, Dong-Sang Suh, Gun Ho Jung, Kyungseok Park, Byung Dae Lee   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

ACE2 ACTIVATION PROMOTES ANTITHROMBOTIC ACTIVITY

The FASEB Journal, 2009
Hyperactivity of the axis ACE/AngII/AT1R of the renin‐angiotensin system is associated with occurrence of acute thrombotic event. Recently a novel concept of a counterrugulatory axis, ACE2/Ang‐(1‐7)/Mas, has emerged. We hypothesized that ACE2 would be protective against thrombosis.
Rodrigo A, Fraga-Silva, Brian S, Sorg, Mamta, Wankhede, Casey, Dedeugd, Joo Y, Jun, Matthew B, Baker, Yan, Li, Ronald K, Castellano, Michael J, Katovich, Mohan K, Raizada, Anderson J, Ferreira   +10 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization

Nature Communications
Sustained Notch2 signals induce trans-differentiation of Follicular B (FoB) cells into Marginal Zone B (MZB) cells in mice, but the physiology underlying this differentiation pathway is still elusive.
Tea Babushku, Markus Lechner, Stefanie Ehrenberg, Ursula Rambold, Marc Schmidt-Supprian, Andrew J. Yates, Sanket Rane, Ursula Zimber-Strobl, Lothar J. Strobl   +8 more
doaj   +1 more source