GAPCNN with HyPar: Global Average Pooling convolutional neural network with novel NNLU activation function and HYBRID parallelism. [PDF]
Front Comput Neurosci, 2022 Habib G, Qureshi S.
europepmc +1 more source
Covalently bound substrate at the regulatory site triggers allosteric enzyme activation
, 2008 The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of ...
Steffen Kutter +11 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A novel activation function based recurrent neural networks and their applications on sentiment classification and dynamic problems solving. [PDF]
Front Neurorobot, 2022 Zhu Q, Tan M.
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Optimal activation of an endogenous gene by HOX11 requires the NH 2- terminal 50 amine acids
, 1998 The HOX11 homeobox gene was first identified through studies of the t(7;10) and t(10;14) chromosomal translocations of acute T-cell leukemia. In addition, analysis of Hox11(-/-) mice has demonstrated a critical role for this gene in murine spleen ...
Masson, N., Greene, W.K., Rabbitts, T.H.
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Position Control of a Pneumatic Drive Using a Fuzzy Controller with an Analytic Activation Function. [PDF]
Sensors (Basel), 2022 Šitum Ž, Ćorić D.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Activation function 1 of progesterone receptor is required for mammary development and regulation of RANKL during pregnancy. [PDF]
Sci Rep, 2022 Lee SH +4 more
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source