Results 161 to 170 of about 2,442,763 (316)

Metabolic regulation of regulatory T cell development and function

, 2014
It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Marelli-Berg, F, Madhav eKishore, Kishore, M, Federica eMarelli-Berg, Federica Marelli-Berg, Coe, DJ, David John Coe, Madhav Kishore   +7 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Unbalanced protocol recognition method based on improved residual U-Net

网络与信息安全学报
An unbalanced protocol recognition method based on the improved Residual U-Net was proposed to solve the challenge of network security posed by the increasing network attacks with the continuous development of the Internet.In the captured network traffic,
Jisheng WU, Zheng HONG, Tiantian MA
doaj   +1 more source

Activation of polyhydroxyalkanoates: functionalization and modification

Frontiers in Bioscience, 2010
Polyhydroxyalkanoates (PHAs) serve numerous bacteria as storage compounds. It is generally believed that under unbalanced growth conditions, n-hydroxyalkanoates are synthesized inside the bacterial cells, polymerized to polyesters, and densely packed in granules.
openaire   +3 more sources

Modified neural network activation function [PDF]

, 2014
Neural Network is said to emulate the brain, though, its processing is not quite how the biological brain really works. The Neural Network has witnessed significant improvement since 1943 to date.
Ibrahim, Adamu Abubakar, Ya’u Gital, Abdulsalam, Maitama, Jafaar, Chiroma, Haruna, Abdulkareem, Sameem, Herawan, Tutut, Abdullahi Muaz, Sanah, Isah, Muhammad Lamir   +7 more
core  

Persistence as function of activation.

, 2014
A) Persistence, P, as a function of activation rate. B) Latent and infectious hosts, and , and the fraction of activation, , as a function of activation rate. The left axis applies to L and I, the right axis to .
Nibiao Zheng (621801), Christopher C. Whalen (116033), Andreas Handel (82914)   +2 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Application of an Improved Graph Neural Network for Drug Property Prediction

IEEE Access
The prediction of drug properties plays a vital role in drug research. However, the drug property prediction accuracy of traditional methods is limited due to their inability to fully capture molecular structure and function information. As a result, the
Xiaopu Ma, Zhan Wang, He Li
doaj   +1 more source

CroReLU: Cross-Crossing Space-Based Visual Activation Function for Lung Cancer Pathology Image Recognition. [PDF]

Cancers (Basel), 2022
Liu Y, Wang H, Song K, Sun M, Shao Y, Xue S, Li L, Li Y, Cai H, Jiao Y, Sun N, Liu M, Zhang T.   +12 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source