Results 201 to 210 of about 17,207,076 (361)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Comparative computational and experimental analyses of some natural small molecules to restore transcriptional activation function of p53 in cancer cells harbouring wild type and p53^Ser46 mutant. [PDF]

Curr Res Struct Biol, 2022
Shefrin S, Sari AN, Kumar V, Zhang H, Meidinna HN, Kaul SC, Wadhwa R, Sundar D.   +7 more
europepmc   +1 more source

RGS3 functions as a tumor promoter by facilitating the activation of the TGF-β signaling pathway and promoting EMT in ovarian cancer. [PDF]

Jinhua Zhou, Zizhao Wang, Huating Sun, Shunpeng Zhu, Fang Wang, Quan Li   +5 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76).

, 2002
Sanjay Awasthi, Rajendra Sharma, Yusong Yang, Sharad S. Singhal, Sławomir Pikuła, Joanna Bandorowicz‐Pikuła, Shivendra V. Singh, Piotr Zimniak, Sanjay Awasthi   +8 more
openalex   +2 more sources

Trainable Highly-Expressive Activation Functions

Accepted to ECCV 2024 on July 1st ...
Irit Chelly, Shahaf E. Finder, Shira Ifergane, Oren Freifeld   +3 more
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Phosphorylation of Syk Activation Loop Tyrosines Is Essential for Syk Function [PDF]

, 2000
Juan Zhang, Melvin L. Billingsley, Randall L. Kincaid, Reuben P. Siraganian   +3 more
openalex   +1 more source

PTPN3 inhibition contributes to the activation of the dendritic cell function to augment the effect of cancer immunotherapy [PDF]

, 2023
Naoya Iwamoto, Hideya Onishi, Syogo Masuda, Akira Imaizumi, Keita Sakanashi, Shinji Morisaki, Shinjiro Nagao, Satoko Koga, Keigo Ozono, Masayo Umebayashi, Takashi Morisaki, Masafumi Nakamura   +11 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source