Results 51 to 60 of about 1,192,982 (215)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Superior stress relaxation resistance of 2.2 GPa martensitic steels and the effect of vanadium

Journal of Materials Research and Technology
For ultra-high-strength steels subjected to sustained loading, stress relaxation resistance is a core indicator determining their long-term service reliability.
Siming Huang, Jianping Ouyang, Liejun Li, Songjun Chen, Xianqiang Xing, Zhuoran Li, Haixiao Ye, Zhengwu Peng, Zhichao Luo   +8 more
doaj   +1 more source

On the strain rate-dependent deformation mechanism of CoCrFeMnNi high-entropy alloy at liquid nitrogen temperature

Materials Research Letters, 2017
In the present work, the deformation mechanisms of the CoCrFeMnNi high-entropy alloy at 77 K were investigated using thermal activation analyses. The strain rate jump test was performed to estimate strain rate sensitivity and the activation volume of the
Jongun Moon, Sun Ig Hong, Jae Wung Bae, Min Ji Jang, Dami Yim, Hyoung Seop Kim   +5 more
doaj   +1 more source

Preparation and characterization of high surface area activated carbon from Fox nut (Euryale ferox) shell by chemical activation with H3PO4

Results in Physics, 2016
Activated carbons were prepared from Fox nutshell by chemical activation with H3PO4 in N2 atmosphere and their characteristics were studied. The effects of activation temperature and impregnation ratio were examined. N2 adsorption isotherms characterized
Arvind Kumar, Hara Mohan Jena
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Investigation of mechanical activation effect on high-volume natural pozzolanic cements

Open Chemistry, 2022
Mechanical activation is one of the most preferred methods to increase the reactivity of mineral, mining, and industrial wastes or materials with low pozzolanic content in cement production.
Korkmaz Abdul Vahap, Kayıran Huseyin Fırat   +1 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source