Results 241 to 250 of about 234,823 (303)

STIM/Orai-Mediated Store-Operated Ca²⁺ Entry in the Pathogenesis of Fibrosis: Mechanisms and Therapeutic Opportunities. [PDF]

Cells
Yi Y, Uddin MN, Killeen K, Gill DL, Zhou Y.   +4 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

How nature discovers rare Turing islands: Exploration by common limit cycles. [PDF]

Proc Natl Acad Sci U S A
Kim S, Matas-Gil A, Endres RG.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Acidosis Regulates Microtubule Dynamics via the β1 Integrin/RhoA/CRMP-2 Axis. [PDF]

J Am Chem Soc
Lachowski D, Cortes E, Mykuliak V, Fernandez-de la Torre M, Bastida Urkiza A, Muñoz-Barrutia A, Garcia-Gonzalez D, Hytönen V, Del Rio Hernandez A.   +8 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

An exploratory plasma-based functional assay for phenotypic characterization of fibrinolysis in dysfibrinogenemia. [PDF]

Res Pract Thromb Haemost
Suzuki A, Okamoto S, Suzuki N, Tamura S, Kanematsu T, Tomita M, Kojima T, Matsushita T.   +7 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Plasminogen Activator Inhibitor 1, Cell Senescence, and Aging-Related Diseases. [PDF]

Cells
Liu RM, Nakamya MF.
europepmc   +1 more source