Results 161 to 170 of about 5,159,180 (362)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

In Vitro Effect of Using Endo-Activator on Pushout Bond Strength of Radicular Dentin to Prefabricated Fiber Post in Using Natural Matrix Metalloproteinase Inhibitors. [PDF]

Clin Exp Dent Res
Elyassi Gorji N, Alaghemand H, Mokhtarpour F, Mahmodnia E.   +3 more
europepmc   +1 more source

Plasminogen activation stimulates an increase in intracellular calcium in human synovial fibroblasts.

, 1993
Mario Gonzalez–Gronow, Govind Gawdi, Salvatore V. Pizzo   +2 more
openalex   +1 more source

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.

Proceedings of the National Academy of Sciences of the United States of America, 2000
Xue-liang Du, D. Edelstein, L. Rossetti, I. G. Fantus, H. Goldberg, F. Ziyadeh, Jie Wu, M. Brownlee   +7 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Performance Verification of High Sensitivity Analyzer for TAT, PIC, TM, and t-PAIC. [PDF]

TH Open
Liu Y, Guo B, Chen G, Chen C, Meng Z, Xie Y, Fan Y, Ma R, Gao L.   +8 more
europepmc   +1 more source

The Timecourse of Activation Within the Cortical Network Associated with Visual Imagery

, 2007
Sharlene D. Newman, Donghoon Lee, Liz Bates   +2 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Steric regulation of CRISPR/Cas12a trans-cleavage kinetics via split-activator extensions. [PDF]

Nucleic Acids Res
Zhang J, He X, Huang J, Cheng C, He G, Xia R, Yang J, Chen J, Guo L, Xiang D, Li F, Shi J, Li P.   +12 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source