Results 1 to 10 of about 63,059 (304)

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran   +7 more
doaj   +1 more source

Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I

Oftalʹmologiâ, 2020
Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively.
N. I. Kurysheva
doaj   +1 more source

Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas [PDF]

, 2012
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 SETAC.An effort is ongoing to develop a biotic ligand model (BLM) that predicts copper (Cu) toxicity in estuarine and marine ...
Anna de Polo, Scrimshaw, MD, Mark D. Scrimshaw, de Polo, A   +3 more
core   +1 more source

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant ...
Tatiana Sharonova, Petr Zhmurov, Stanislav Kalinin, Alessio Nocentini, Andrea Angeli, Marta Ferraroni, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +1 more source

Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Breast Cancer Research, 2023
Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing.
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer   +13 more
doaj   +1 more source

Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the intracellular and extracellular pH in hypoxic tumours abetting the metastasis of solid tumours.
Shaik Mahammad Ghouse, Kavyaraj Bahatam, Andrea Angeli, Gaurav Pawar, Krishna Kartheek Chinchilli, Venkata Madhavi Yaddanapudi, Arifuddin Mohammed, Claudiu T. Supuran, Srinivas Nanduri   +8 more
doaj   +1 more source

Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials

Critical Care, 2018
Background Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus reverse metabolic alkalosis.
Bassem Y Tanios, Maryam O Omran, Carlos Noujeim, Tamara Lotfi, Samir S Mallat, Pierre K Bou-Khalil, Elie A Akl, Houssam S Itani   +7 more
doaj   +1 more source

Role of carbon dioxide and ion transport in the formation of sub-embryonic fluid by the blastoderm of the Japanese quail

, 2002
1. The explanted blastoderm of the Japanese quail was used to explore the role of ions and carbon dioxide in determining the rate of sub-embryonic fluid (SEF) production between 54 and 72 h of incubation. 2.
Latter, G.V., Baggott, Glenn K.
core   +1 more source

Characteristics of Carbonatogenic Bacteria and Their Role in Enhancing the Stability of Biocrusts in Tropical Coral Islands

Microorganisms
Soil erosion is a serious environmental problem that leads to land degradation and ecological imbalance, thereby eliciting extensive and profound worldwide concern.
Qiqi Chen, Lin Wang, Jie Li, Qiqi Li, Hongfei Su, Zhimao Mai   +5 more
doaj   +1 more source

Effect of egg turning and incubation time on carbonic anhydrase gene expression in the blastoderm of the Japanese quail (Coturnix c. japonica)

, 2008
(1) The gene expression of carbonic anhydrase, a key enzyme for the production sub-embryonic fluid (SEF), was assessed in turned and unturned eggs of the Japanese quail.
Baggott, G. K., Baggott, Glenn K., Sugden, D, Sugden, D., de Winter, Patricia, De Winter, P.   +5 more
core   +1 more source