Results 21 to 30 of about 77,334 (297)

Evidencing the role of carbonic anhydrase in the formation of carbonate minerals by bacterial strains isolated from extreme environments in Qatar

Heliyon, 2022
Calcium carbonate, one of the most abundant minerals in the geological records is considered as primary source of the carbon reservoir. The role of microorganisms in the biotic precipitation of calcium carbonate has been extensively investigated ...
Rim Abdelsamad, Zulfa Al Disi, Mohammed Abu-Dieyeh, Mohammad A. Al-Ghouti, Nabil Zouari   +4 more
doaj   +1 more source

Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

Acta Dermato-Venereologica, 2018
Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological ...
Bani Kaur Suri, Navin Kumar Verma, Artur Schmidtchen   +2 more
doaj   +1 more source

A clinical case of choroidal effusion associated with the use of carbonic anhydrase inhibitors

Офтальмохирургия, 2021
Relevance. Choroidal effusion is a complication accompanying both surgical interventions and ophthalmopathies of predominantly inflammatory etiology. The release of proteins from choriocapillaries lumen and decrease of intraocular pressure relative to ...
N. I. Kurysheva, O. A. Pererva, A. A. Ivanova, G. A. Sharova   +3 more
doaj   +1 more source

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran   +7 more
doaj   +1 more source

Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I

Oftalʹmologiâ, 2020
Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively.
N. I. Kurysheva
doaj   +1 more source

Conformational effects on the Circular Dichroism of Human Carbonic Anhydrase II: a multilevel computational study [PDF]

, 2013
Circular Dichroism (CD) spectroscopy is a powerful method for investigating conformational changes in proteins and therefore has numerous applications in structural and molecular biology. Here a computational investigation of the CD spectrum of the Human
Uno Carlsson, Kia Balali-Mood (210078), Karabencheva-Christova, Tatyana G, Balali-Mood Kia, Gary W. Black (382116), Black Gary W., Carlsson, Uno,, Kia Balali-Mood, Christov, Christo Z., Carlsson, Uno, Balali-Mood, Kia,, Christo Z Christov, Christov, Christo, Christov Christo Z., Karabencheva-Christova, Tatyana G,, Tatyana G. Karabencheva-Christova (382114), Uno Carlsson (382115), Black, Gary W., Karabencheva-Christova, Tatyana, Christo Z. Christov (382117), Tatyana G Karabencheva-Christova, Balali-Mood, Kia, Karabencheva-Christova Tatyana G., Carlsson Uno, Black, Gary W.,, Gary W Black, Black, Gary, Christov, Christo Z.,   +27 more
core   +1 more source

A new role for carbonic anhydrase 2 in the response of fish to copper and osmotic stress: Implications for multi-stressor studies [PDF]

, 2014
Copyright @ 2014 de Polo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
de Polo Anna, Scrimshaw, Mark D., Scrimshaw Mark D., Scrimshaw, MD, De Polo, A, Margiotta-Casaluci, Luigi; id_orcid, Margiotta-Casaluci, L, Margiotta-Casaluci Luigi, Lockyer, AE, Mark D. Scrimshaw (637445), Lockyer Anne E., de Polo, Anna, Anna de Polo, Anne E. Lockyer (107520), Luigi Margiotta-Casaluci, Margiotta-Casaluci, Luigi, Mark D Scrimshaw, Luigi Margiotta-Casaluci (637444), Lockyer, Anne E., Anna de Polo (637443), Anne E Lockyer   +20 more
core   +1 more source

Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Breast Cancer Research, 2023
Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing.
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer   +13 more
doaj   +1 more source

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant ...
Tatiana Sharonova, Petr Zhmurov, Stanislav Kalinin, Alessio Nocentini, Andrea Angeli, Marta Ferraroni, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +1 more source

Prokaryotic carbonic anhydrases [PDF]

FEMS Microbiology Reviews, 2000
Carbonic anhydrases catalyze the reversible hydration of CO(2) [CO(2)+H(2)Oright harpoon over left harpoon HCO(3)(-)+H(+)]. Since the discovery of this zinc (Zn) metalloenzyme in erythrocytes over 65 years ago, carbonic anhydrase has not only been found in virtually all mammalian tissues but is also abundant in plants and green unicellular algae.
K S, Smith, J G, Ferry
openaire   +2 more sources