Results 41 to 50 of about 101,552 (276)

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant ...
Tatiana Sharonova, Petr Zhmurov, Stanislav Kalinin, Alessio Nocentini, Andrea Angeli, Marta Ferraroni, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +1 more source

Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Breast Cancer Research, 2023
Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing.
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer   +13 more
doaj   +1 more source

Peptide-Gold Nanoparticle Conjugates as Artificial Carbonic Anhydrase Mimics [PDF]

, 2019
We herein describe the design and synthesis of a catalytically active peptide–gold nanoparticle conjugate (Pep-Au-NP) that binds Zn(II) within its peptide monolayer and develops carbonic anhydrase activity. Specifically, a modified variant of the β-sheet
Koksch, Beate, Mikolajczak, Dorian J.
core   +1 more source

Conformational effects on the Circular Dichroism of Human Carbonic Anhydrase II: a multilevel computational study [PDF]

, 2013
Circular Dichroism (CD) spectroscopy is a powerful method for investigating conformational changes in proteins and therefore has numerous applications in structural and molecular biology. Here a computational investigation of the CD spectrum of the Human
A Roy, B Hess, BM Bulheller, BM Bulheller, C Christov, C Christov, C Christov, C Christov, C Christov, C Christov, CD Andrew, Christo Z. Christov, D Robinson, D Robinson, DM Rogers, DM Rogers, Gary W. Black, HJC Berendsen, J Hudecova, K Hakansson, Kia Balali-Mood, M Karplus, M Karplus, M Li, ME Casida, N Berova, NA Besley, P-O Freskgaard, PM Bayley, R Rodriguez, RW Woody, RW Woody, S Lindskog, SA Adcock, SM Kelly, T Karabencheva, T Karabencheva, Tatyana G. Karabencheva-Christova, U Essmann, Uno Carlsson, Vladimir N. Uversky, W Humphrey, WJ Goux   +42 more
core   +7 more sources

The sheep conceptus modulates proteome profiles in caruncular endometrium during early pregnancy [PDF]

, 2016
This project was funded by NHS Grampian R&D project number RG05/019Peer ...
Al-Gubory, Kaïs, Arianmanesh, Mitra, Fowler, Paul A   +2 more
core   +2 more sources

Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials

Critical Care, 2018
Background Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus reverse metabolic alkalosis.
Bassem Y Tanios, Maryam O Omran, Carlos Noujeim, Tamara Lotfi, Samir S Mallat, Pierre K Bou-Khalil, Elie A Akl, Houssam S Itani   +7 more
doaj   +1 more source

Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the intracellular and extracellular pH in hypoxic tumours abetting the metastasis of solid tumours.
Shaik Mahammad Ghouse, Kavyaraj Bahatam, Andrea Angeli, Gaurav Pawar, Krishna Kartheek Chinchilli, Venkata Madhavi Yaddanapudi, Arifuddin Mohammed, Claudiu T. Supuran, Srinivas Nanduri   +8 more
doaj   +1 more source

Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas [PDF]

, 2012
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 SETAC.An effort is ongoing to develop a biotic ligand model (BLM) that predicts copper (Cu) toxicity in estuarine and marine ...
de Polo, A, Scrimshaw, MD
core   +1 more source

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

Characteristics of Carbonatogenic Bacteria and Their Role in Enhancing the Stability of Biocrusts in Tropical Coral Islands

Microorganisms
Soil erosion is a serious environmental problem that leads to land degradation and ecological imbalance, thereby eliciting extensive and profound worldwide concern.
Qiqi Chen, Lin Wang, Jie Li, Qiqi Li, Hongfei Su, Zhimao Mai   +5 more
doaj   +1 more source