Results 51 to 60 of about 101,552 (276)

A De Novo Designed Metalloenzyme for the Hydration of CO 2 [PDF]

, 2014
Protein design will ultimately allow for the creation of artificial enzymes with novel functions and unprecedented stability. To test our current mastery of nature’s approach to catalysis, a Zn II metalloenzyme was prepared using de novo design.
Brown, Brown, Bryson, Chakraborty, Der, Faiella, Fierke, Huguet, Hunt, Jackman, Jewell, Kaplan, Khalifah, Khare, Koziol, Krebs, Looney, Nakata, Nakata, Reig, Richardson, Rufo, Slebocka-Tilk, Song, Tegoni, Walsh, Walsh, Woolley, Yamaguchi, Yu, Zastrow, Zastrow, Zhang, Zhang   +33 more
core   +1 more source

Alpha Carbonic Anhydrase 5 Mediates Stimulation of ATP Synthesis by Bicarbonate in Isolated Arabidopsis Thylakoids

Frontiers in Plant Science, 2021
We studied bicarbonate-induced stimulation of photophosphorylation in thylakoids isolated from leaves of Arabidopsis thaliana plants. This stimulation was not observed in thylakoids of wild-type in the presence of mafenide, a soluble carbonic anhydrase ...
Tatiana P. Fedorchuk, Inga A. Kireeva, Vera K. Opanasenko, Vasily V. Terentyev, Natalia N. Rudenko, Maria M. Borisova-Mubarakshina, Boris N. Ivanov   +6 more
doaj   +1 more source

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis, Rita Meleddu, Andrea Angeli, Simona Distinto, Giulia Bianco, Clemente Capasso, Filippo Cottiglia, Rossella Angius, Claudiu T. Supuran, Elias Maccioni   +9 more
doaj   +1 more source

Effects of low seawater pH on the marine polychaete Platynereis dumerilii [PDF]

, 2015
An important priority for any organism is to maintain internal cellular homeostasis including acidbase balance. Yet, the molecular level impacts of changing environmental conditions, such as low pH, remain uncharacterised.
Arendt, Detlev, Chapman, Emma C., Hardege, Joerg D., Hardege, Jörg D., Larsson, Tomas A., Rotchell, Jeanette M., Simakov, Oleg, Waege, Janine, Wäge, Janine   +8 more
core   +1 more source

The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance [PDF]

, 2013
Taste sensitivity to PROP varies greatly among individuals and is associated with polymorphisms in the bitter receptor gene TAS2R38, and with differences in fungiform papilla density on the anterior tongue surface.
Atzori E, Cabras S, Calò C, Melis M, Muroni P, Nieddu M, Padiglia A, Sogos V, Tepper BJ, Tomassini Barbarossa I, Zonza A   +10 more
core   +1 more source

5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin, Alexander Kovalenko, Annika Valtari, Alessio Nocentini, Maxim Gureev, Arto Urtti, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin   +8 more
doaj   +1 more source

Carbonic Anhydrase Inhibitors

Kidney and Blood Pressure Research, 1987
The purpose of the present review is to describe the use of carbonic anhydrase inhibitors in clinical medicine and renal physiology. We first describe the localization of carbonic anhydrase within the kidney and then discuss evidence for its role in renal acidification and NaCl absorption.
P A, Preisig, R D, Toto, R J, Alpern
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

First episode psychotic disorder possibly associated with acetazolamide in a male adolescent with congenital glaucoma [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2015
Primer congenital glaucoma is an uncommon ophthalmological disease manifesting at birth and accounting for 0.01-0.04% of total blindness. Acetozalamide, a carbonic anhydrase inhibitor is one of the options in the medical treatment of glaucoma and acute ...
ozhan yalcin
doaj  

Acetazolamide in the treatment of acute mania - A case report [PDF]

, 1998
Several antiepileptic drugs are also being used in affective disorders. There are some hints that also the carbonic anhydrase inhibitor acetazolamide might be useful in the treatment of bipolar affective disorder.
Brandt, C., Grunze, Heinz, Normann, C., Walden, Jörg   +3 more
core   +1 more source