Role of the Matrix Metalloproteinase and Plasminogen Activator-Plasmin Systems in Angiogenesis
Arteriosclerosis, Thrombosis and Vascular Biology, 2001 M. Pepper
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Prospective validation of the prognostic and predictive impact of uPA/PAI-1 in early breast cancer. [PDF]
Breast Cancer Res TreatWieder V +16 more
europepmc +1 more source
Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex
Science, 2012 Nian Huang +8 more
semanticscholar +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
PlantReg 1.1 identifies the mutual arrangement of transcription factor binding sites in the target promoters for the elucidation of molecular mechanisms within regulatory networks. [PDF]
Vavilovskii Zhurnal Genet SelektsiiLavrekha VV +5 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Correction: THRUST: translesion synthesis-driven hierarchical regulation using a template-activator construct for Cas12a activity. [PDF]
Chem SciQin L +12 more
europepmc +1 more source