Results 241 to 250 of about 1,301,037 (308)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Lymphatic Malformations With Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases. [PDF]

Arterioscler Thromb Vasc Biol
Mastrogiacomo DM, Price A, Fu Y, Banerjee R, Knauer LA, Li K, Yang Y, Davis GE, Dellinger MT, Scallan JP.   +9 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Sustainable valorization of copper mine waste into construction materials by alkali activation. [PDF]

Sci Rep
Fattahi SM, Nastooh MY, Heydari A, Ebadi T.   +3 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Negative-Pressure Induces Epithelial-Mesenchymal Transition via Thrombospondin-1 Upregulation in Intact Diabetic Skin. [PDF]

Int Wound J
Yamashiro T, Kushibiki T, Mayumi Y, Tsuchiya M, Ishihara M, Azuma R.   +5 more
europepmc   +1 more source

Effectiveness of intravenous recombinant plasminogen activator treatment in Chinese patients with acute ischaemic stroke aged over 80 years: a retrospective cohort study. [PDF]

Stroke Vasc Neurol
Yang J, Huang YH, Zhong W, Gong X, Chen Y, Chen Z, Jin H, Yan S, Huang L, Yuan CZ, Lou M.   +10 more
europepmc   +1 more source

Development of one part sustainable alkali activated binder system using slag, flyash and micro calcined kaolin. [PDF]

Sci Rep
Girish MG, Prashant S, Jagadisha HM, Prabha S.   +3 more
europepmc   +1 more source

A tailored phosphorothioate coordinator enables CRISPR/Cas in-situ amplification. [PDF]

Nucleic Acids Res
Yang T, Tang M, Xu L, Jiang L, Jiang L, Zou Y, Wang J, Liu Z, Chen F, Ban Y, Ren W, Cheng W.   +11 more
europepmc   +1 more source

Steric regulation of CRISPR/Cas12a trans-cleavage kinetics via split-activator extensions. [PDF]

Nucleic Acids Res
Zhang J, He X, Huang J, Cheng C, He G, Xia R, Yang J, Chen J, Guo L, Xiang D, Li F, Shi J, Li P.   +12 more
europepmc   +1 more source