Results 281 to 290 of about 4,610,135 (394)

Functional Characterization of Glucokinase Variants to Aid Clinical Interpretation of Monogenic Diabetes. [PDF]

Int J Mol Sci
Rajesh V, Ibarra DE, Yang J, Zhang H, Barrett A, Kaplan EG, Kumthekar A, Sunden F, Sun H, Addala A, Misakian A, Letourneau-Freiberg LR, Jodarski CO, Maloney KA, Saint-Martin C, Fordyce PM, Pollin TI, Gloyn AL.   +17 more
europepmc   +1 more source

Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb: genetics and functional aspects [PDF]

Fábio Jean Varella, Fernando Antônio Costa Xavier, Gabriele Zanirati, João Ismael Budelon Gonçalves, Thales Thor Ramos Previato, Douglas Bottega Pazzin, Normando G Pereira-Neto, Eliseu Paglioli, William Alves Martins, André Palmini, Adriana Souza dos Santos, José G. Abreu, Kamila Souto Leichtweis, Denise Cantarelli Machado, Jaderson Costa da Costa, Daniel Rodrigo Marinowic   +15 more
openalex   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus. [PDF]

PLoS One
Kraycer PM, Gartenberg MR.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Predictive modeling of gene expression and localization of DNA binding site using deep convolutional neural networks. [PDF]

PLoS Comput Biol
Karshenas A, Röschinger T, Garcia HG.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Mucopolysaccharidosis type VI in the Russian registry: Further insights and considerations. [PDF]

World J Clin Pediatr
Malik S.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

How transcriptional networks control Verticillium plants infection. [PDF]

PLoS Pathog
Chen YY, Harting R, Braus GH.
europepmc   +1 more source