Results 371 to 380 of about 3,917,874 (426)
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Genetic and Non-Genetic Determinants of the Pharmacological Activity of Statins
Current Drug Metabolism, 2016Statins are cholesterol-lowering agents which belong to the group of the most commonly prescribed drugs. The use of statins has become the standard treatment in patients with an increased risk of cardiovascular and coronary heart diseases. However, many clinical studies have shown that 13 - 75% of patients fail to achieve LDL-cholesterol and total ...
Jakub Mikolajewski +3 more
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Genetic Factors in Activity Motivation
Child Development, 1966A study of 61 pairs of identical (MZ) and fraternal (DZ) grade-school twin girls found moderate genetic contributions to individual differences in several aspects of activity motivation: reaction time, variety of activity, anxiety, and impatience. Activity motivation was defined by empirical clusters of related measures including ratings, experimental ...
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Activities of the National Institute of Genetics
Nature, 1972Active research involving many different aspects of genetics has led to exciting discoveries at the National Institute of Genetics.
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Genetic activity of vinylidene chloride in yeast
Mutation Research/Genetic Toxicology, 1981Vinylidene chloride (VDC) was tested for its ability to induce both point mutation and mitotic gene conversion in a diploid strain (D7) of the yeast Saccharomyces cerevisiae in a suspension test with and without a mammalian microsomal activation system, and in the intrasanguineous host-mediated assay in mice. In suspension tests with D7, VCD was toxic
Carlo Bauer +5 more
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Advances in Oto-Rhino-Laryngology, 2011
There is a growing body of evidence, both from animal and human studies, that host genetic factors can influence the risk of developing otitis media (OM). The role of genetics in OM has been elucidated through studies with monozygotic and dizygotic twins,
J. Post
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There is a growing body of evidence, both from animal and human studies, that host genetic factors can influence the risk of developing otitis media (OM). The role of genetics in OM has been elucidated through studies with monozygotic and dizygotic twins,
J. Post
semanticscholar +1 more source
Genetic Vaccination for the Active Immunotherapy of Cancer
Current Gene Therapy, 2001Molecular biology techniques have given novel impetus to the immunotherapy of cancer because they have catalyzed the identification of several potential tumor antigens, and permitted the generation of vectors for the delivery of genetic material encoding these antigens.
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Genetically encoded neural activity indicators
Current Opinion in Neurobiology, 2012Recording activity from identified populations of neurons is a central goal of neuroscience. Changes in membrane depolarization, particularly action potentials, are the most important features of neural physiology to extract, although ions, neurotransmitters, neuromodulators, second messengers, and the activation state of specific proteins are also ...
Loren L. Looger, Oliver Griesbeck
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Genetic epidemiology of induced CYP3A4 activity
Pharmacogenetics and Genomics, 2011The cytochrome P450 3A4 (CYP3A4) enzyme is implicated in the metabolism of more than 50% of all prescribed medications and its activity - including induced or inhibited activity - is deemed to be a crucial determinant of interindividual variability in drug disposition, poor therapeutic efficacy, and adverse response to medication.We used the classical ...
Rahmioglu, Nilufer +10 more
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Genetic differences in locomotor activation in mice
Pharmacology Biochemistry and Behavior, 1986Two highly inbred strains of mice were found to differ in habituation of activity repeatedly assessed in a toggle-box exploration task. The recombinant inbred (RI) strains derived from their cross resembled either one or the other parent strain, suggesting that a single gene exerts a marked influence on this behavior.
John C. Crabbe, John C. Crabbe
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Genetical Aspects of Active Defence [PDF]
, 1982 I find myself in a rather uncomfortable position in presenting this paper. The reason for this is that what I have to say does not support much of the speculation and dogma that has been presented in preceding papers. I feel like a non-believer in a congregation of believers.
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