Results 221 to 230 of about 3,292,938 (307)

Long-Term Outcomes of Mitral Valve Repair with Limited Resection in Active Endocarditis. [PDF]

J Cardiovasc Dev Dis
Haidari Z, Turaev I, Demircioglu E, Knipp S.   +3 more
europepmc   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action. [PDF]

Diabetes
Waterman HL, Smith MS, Farmer B, Yankey K, Howard T, Kraft G, Cherrington AD, Edgerton DS.   +7 more
europepmc   +1 more source

Van der Waals Heterostructures for Next‐Generation Spintronics: Multiferroic‐Mediated Magnetoelectric Properties

Advanced Science, EarlyView.
As CMOS technology approaches fundamental energy limits, new paradigms for low‐power information processing are required. Magnetic systems are attractive for their spin transport, yet current‐induced magnetization control is energy inefficient. Multiferroic heterostructures enable energy‐efficient electric field manipulation of magnetism.
Donghyeon Lee, Jiwoong Yang, Inhyeok Oh, Sanghan Lee   +3 more
wiley   +1 more source

Structural basis for independent pore function of Vpb4 from Bacillus thuringiensis. [PDF]

Nat Commun
Wirawan R, Jamieson WD, Baird HM, Berry C, Lupton CJ, Venugopal H, Valentin-Alvarado LE, Best HL, Jones DD, Williamson LJ, Auhim HS, Castell OK, Dunstone MA, Spicer BA.   +13 more
europepmc   +1 more source

Novel Active Clamp Tappped Inductor Converter

Record of Joint Conference of Electrical and Electronics Engineers in Kyushu, 2005
Nisijima, Kimihiro, Abe, Kosuke, Harada, Kosuke, Nakano, Tadao, Nabesima, Takashi, Sato, Terukazu   +5 more
openaire   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

STX1B variant-specific synaptic dysfunction is associated with network hyperexcitability in human iPSC-derived neurons. [PDF]

EBioMedicine
Haag C, Gsell F, Vinogradov O, Oquendo MB, Liu Y, Uysal B, Löffler H, Stehle F, Klopfer F, Crönlein J, Böttcher K, Toonen RF, Muhle H, Kohl B, Lerche H, Schwarz N.   +15 more
europepmc   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Minimally Invasive Ross Procedure in Adults, Through an Arrow-Shaped ("V" Shaped) Ministernotomy Approach. [PDF]

J Clin Med
Shadmanian A, Patel K, Szabó-Biczók A, Varga S, Donauer T, Agócs S, Balogh ÁL, Bitay M.   +7 more
europepmc   +1 more source