Results 51 to 60 of about 80,800 (296)

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Electrophysiological Properties of Neurons: Current-Clamp Recordings in Mouse Brain Slices and Firing-Pattern Analysis

Bio-Protocol, 2021
Characterization of an electrically active cell, such as a neuron, demands measurement of its electrical properties. Due to differences in gene activation, location, innervation patterns, and functions, the millions of neurons in the mammalian brain are ...
Elina Nagaeva, Ivan Zubarev, Esa Korpi
doaj   +1 more source

Forward with Active Clamp for space applications: clamp capacitor, dynamic specifications and EMI filter impact on the power stage design [PDF]

, 2017
The impact of the clamp capacitor design, the dynamic specifications and the EMI filter design on the power stage design of a 28V 50W Forward with Active Clamp converter for space applications is analyzed along this paper.
Cobos, J.A., Oliver, J.A., Salinas, Guillermo, Stevanovic, Branislav, Vasic, M.   +4 more
core  

A review on flicker-free ac-dc LED drivers for single-phase and three-phase ac power grids [PDF]

, 2019
Light-Emitting Diodes (LEDs) are coming strongly into the lighting market due to their advantages over conventional lighting solutions: energy efficient, controllable in both light and color, long lifetime, lack of a warm-up period and high power density.
Arias Pérez de Azpeitia, Manuel, Castro Álvarez, Ignacio, González Lamar, Diego, Hernando Álvarez, Marta María, Sebastián Zúñiga, Francisco Javier, Vázquez Ardura, Aitor   +5 more
core   +2 more sources

3D‐Printed Serial Snap‐Through Architectures for Programmable Mechanical Response

Advanced Engineering Materials, EarlyView.
A serial snap‐through architecture is realized using compact 3D‐printed von Mises truss units arranged in a staged cascade. Their geometry and boundary conditions program multistage mechanical responses with plateaux and re‐hardening regimes. An inverted‐compliance model predicts these behaviors and enables analytical design of programmable force ...
Filipe A. Santos
wiley   +1 more source

High-Efficiency Design and Control of Zeta Inverter for Single-Phase Grid-Connected Applications

Energies, 2019
The conventional zeta inverter has been used for single-phase grid-connected applications. However, it has high switching losses to operate at high switching frequency in the continuous conduction mode (CCM). To address this drawback, this paper suggests
Woo-Young Choi, Min-Kwon Yang
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

ZVZCS PWM Converter Using Secondary Active Clamp

Acta Electrotechnica et Informatica, 2011
A novel zero-voltage and zero-current switching (ZVZCS) pulse-width modulation (PWM) converter is presented in this paper. An active energy recovery clamp in the secondary side provides conditions for zero-current switching (ZCS) of the transistors in the primary side of the DC/DC converter.
Marcel Bodor, Jaroslav Dudrik, Ján Perduľak   +2 more
openaire   +1 more source

Photocatalytic Versus Stoichiometric Hydrogen Generation Using Mesoporous Silicon Catalysts: The Complex Role of Sacrificial Reagents

Advanced Functional Materials, EarlyView.
This study highlights the importance of accounting for stoichiometric hydrogen produced when utilizing Si photocatalysts. The stoichiometric contribution is sacrificial reagent dependent and decreases with increasing sterics around the catalyst surface.
Sarrah H. Putwa, Sarah A. Martell, Berthold Reis, Simona Schwarz, Mita Dasog   +4 more
wiley   +1 more source

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trialResearch in context

EBioMedicine, 2023
Summary: Background: We previously demonstrated the safety and immunogenicity of an MF59-adjuvanted COVID-19 vaccine based on the SARS-CoV-2 spike glycoprotein stabilised in a pre-fusion conformation by a molecular clamp using HIV-1 glycoprotein 41 ...
Keith J. Chappell, Francesca L. Mordant, Alberto A. Amarilla, Naphak Modhiran, Benjamin Liang, Zheyi Li, Danushka K. Wijesundara, Julia A. Lackenby, Paul Griffin, Jillian K. Bennet, Luca Hensen, Wuji Zhang, Thi H.O. Nguyen, Mai H. Tran, Peter Tapley, James Barnes, Patrick C. Reading, Katherine Kedzierska, Charani Ranasinghe, Kanta Subbarao, Daniel Watterson, Paul R. Young, Trent P. Munro   +22 more
doaj   +1 more source