Results 131 to 140 of about 1,085,897 (278)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

PARTICULARITIES OF THE POPULATION, OCCUPATION AND STRUCTURE OF UNEMPLOYMENT IN ROMANIA AND ITS WESTERN REGION [PDF]

open access: yes
Amid a slow process, but continually aging and a trend of increased migration isa decrease in the active population and employment. Productive structure has undergoneseveral changes in recent years, with a mild increase in service sector, what has ...
Gherghel Silvia
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Physical Activity Modulates Corticospinal Excitability of the Lower Limb in Young and Old Adults [PDF]

open access: yes, 2017
Aging is associated with reduced neuromuscular function, which may be due in part to altered corticospinal excitability. Regular physical activity (PA) may ameliorate these age-related declines, but the influence of PA on corticospinal excitability is ...
Hassanlouei, Hamidollah   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Sexual activity and successful aging [PDF]

open access: yesEuropean Geriatric Medicine, 2022
Soysal, PINAR, Smith, Lee
openaire   +3 more sources

Walking in the cement forest: a health enhancement and pedometer-determined ambulatory (HEPA) program in Hong Kong [PDF]

open access: yes, 2012
Congress Theme: A Celebration of Diversity and Inclusion in Active AgeingThis journal suppl.entitled: Supplement issue: Abstracts for the 8th World Congress on Ageing and Physical Activitypublished_or_final_versionThe 8th Annual World Congress on Active ...
Cheung, MKT   +5 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Expectativas hacia la jubilación del personal de la Universidad de Santiago de Compostela Retirement expectations of the staff of the University of Santiago de Compostela

open access: yesGerokomos, 2006
Involucrados en la importancia que el fenómeno jubilación tiene en la actualidad, hemos llevado a cabo un estudio sobre las expectativas hacia la misma de un grupo de trabajadores de la Universidad de Santiago de Compostela (USC), cuestionando parámetros
Ana María Cal Crespo   +3 more
doaj  

Comparison of the toxicokinetics of daidzein and bisphenol A in pregnant and non-pregnant DA/Han rats [PDF]

open access: yes
Potentially adverse human and environmental effects due to hormone mimicry of environmental estrogens are a matter of current concern. Environmental estrogens belong to the socalled endocrine active compounds (EAC) and may alter signalling processes of ...
Degen, Gisela H., Selinski, Silvia
core  

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