Results 91 to 100 of about 715,328 (344)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Automatic Balancing of a Rotor-Bearing System: On-line Algebraic Identifier for a Rotordynamic Balancing System

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2016
A methodology for simultaneously balancing of several modes of vibration for a rotor bearing system by mean the so-called active balancing disk is presented in this paper.
J.G. Mendoza Larios, J. Colín Ocampo, A. Blanco Ortega, A. Abúndez Pliego, E.S. Gutiérrez Wing   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Optimization of silicon solar cell design for use under concentrated solar irradiation

Технологія та конструювання в електронній апаратурі
The study considers the structure of multimodular batteries (on the example of electric vehicle batteries), cell configuration, chemical composition and capacity of the elements that form the cells. The authors compare the battery characteristics of most
Roman Korkishko, Viktor Vlasiuk, Vitaliy Kostylyov, Volodymyr Chernenko, Boris Dvernikov   +4 more
doaj   +1 more source

Battery Management System—Balancing Modularization Based on a Single Switched Capacitor and Bi-Directional DC/DC Converter with the Auxiliary Battery

Energies, 2014
Lithium-based batteries are considered as the most advanced batteries technology, which can be designed for high energy or high power storage systems.
Mohamed Daowd, Mailier Antoine, Noshin Omar, Philippe Lataire, Peter Van Den Bossche, Joeri Van Mierlo   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Binary PSOGSA for Load Balancing Task Scheduling in Cloud Environment

, 2018
In cloud environments, load balancing task scheduling is an important issue that directly affects resource utilization. Unquestionably, load balancing scheduling is a serious aspect that must be considered in the cloud research field due to the ...
Alnusairi, Thanaa S., Daadaa, Yassine, Shahin, Ashraf A.   +2 more
core   +1 more source

Hierarchical Structure-Based Wireless Active Balancing System for Power Batteries

Energies
This paper conducts an in-depth study of a wireless, hierarchical structure-based active balancing system for power batteries, aimed at addressing the rapid advancements in battery technology within the electric vehicle industry.
Jia Xie, Huipin Lin, Jifeng Qu, Luhong Shi, Zuhong Chen, Sheng Chen, Yong Zheng   +6 more
doaj   +1 more source

Brain Activation During Active Balancing and Its Behavioral Relevance in Younger and Older Adults: A Functional Near-Infrared Spectroscopy (fNIRS) Study. [PDF]

Front Aging Neurosci, 2022
Lehmann N, Kuhn YA, Keller M, Aye N, Herold F, Draganski B, Taube W, Taubert M.   +7 more
europepmc   +1 more source