Results 181 to 190 of about 3,071,772 (281)

Strategies for pro-active case-finding in leprosy control

Leprosy Review, 2000
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Impact of the use of the ultra-portable digital x-ray with CAD4TB for active case finding for tuberculosis in Nigeria. [PDF]

Front Digit Health
Alege A, Useni S, Ihesie A, Eneogu R, Agbaje A, Odume B, Nongo D, Chukwu E, Ogbudebe C, Oyelaran O, Anyomi C, Akingbesote S, Qin ZZ, Barrett R, Chijioke-Akaniro O, Anyaike C, Ewa A.   +16 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Should neighbours of tuberculosis (TB) cases be prioritised for active case finding in high TB-burden settings? A prospective molecular epidemiological study. [PDF]

BMJ Glob Health
Koesoemadinata RC, McAllister S, Huang CC, Hartati S, Djunaedy H, Dewi NF, Chaidir L, Lestari BW, Hadisoemarto PF, Van Crevel R, Murray MB, Alisjahbana B, Hill PC.   +12 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Detect early TB infection, evaluate contacts for TB (DETEC-TB) - a protocol for a prospective cohort study on active case finding for tuberculosis disease and tuberculosis infection source tracing. [PDF]

BMC Infect Dis
Amour M, Joseph P, Ngowi J, Issa A, Moshiro C, Ruhago G, Munseri P, Balandya E, Fundikira L, Horsburgh CR, Whalen CC, Matee M, von Reyn CF.   +12 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Sputum pooling for rapid and cost-effective active case-finding for TB in prisons. [PDF]

Int J Tuberc Lung Dis
Batestin D, Busatto C, Salindri AD, da Silva Santos A, Lemes IBG, Pereira Dos Santos PC, Lemos EF, Gonçalves TO, Cunha EAT, de Oliveira RD, Andrews JR, Croda J.   +11 more
europepmc   +1 more source

Undiagnosed (or Unrecognized) Chronic Obstructive Pulmonary Disease and Asthma: Does Active Case Finding Identify Clinically Impaired Patients with Treatment Potential? [PDF]

Am J Respir Crit Care Med, 2023
Çolak Y.
europepmc   +1 more source