Results 41 to 50 of about 783,140 (262)

The impact of active case finding on transmission dynamics of tuberculosis: A modelling study

open access: yesPLOS ONE, 2021
Background In the last decade, active case finding (ACF) strategies for tuberculosis (TB) have been implemented in many diverse settings, with some showing large increases in case detection and reporting at the sub-national level. There have also been several studies which seek to provide evidence for the benefits of ACF to individuals and communities
Diepreye Ayabina   +8 more
openaire   +6 more sources

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook   +6 more
wiley   +1 more source

Active screening for pulmonary tuberculosis among migrant workers and their families residing in Puducherry

open access: yesDiscover Public Health
Background TB remains a major public health challenge worldwide, with India contributing nearly one-fourth of the global TB burden. Migrant workers face barriers to healthcare access, delayed diagnosis, and poor health-seeking behavior.
Aravind Siddharth Radhakrishnan   +5 more
doaj   +1 more source

Ending the TB epidemic – what can we learn from the HIV epidemic?

open access: yesIJTLD Open
Advocates for community-wide screening promote this approach to reduce TB incidence and end the TB epidemic. The roll-out of antiretroviral therapy (ART) for HIV-infected people is often cited as evidence that such ambitious programmes can work, even in ...
A.D. Harries
doaj   +1 more source

Leveraging tuberculosis case relative locations to enhance case detection and linkage to care in Swaziland

open access: yesGlobal Health Research and Policy, 2018
Background In Swaziland, as in many high HIV/TB burden settings, there is not information available regarding the household location of TB cases for identifying areas of increased TB incidence, limiting the development of targeted interventions.
Marie Brunetti   +7 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási   +14 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

“Knock Knock”: a qualitative study exploring the experience of household contacts on home visits and their attitude towards people living with TB in South Africa

open access: yesBMC Public Health, 2020
Background Household contract tracing (HHCT) is an important strategy for active tuberculosis case finding and offers an opportunity for testing of other diseases such as HIV. However, there is limited data on the patient-centered approach to HHCT.
Farzana Sathar   +4 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli   +3 more
wiley   +1 more source

HIV Infection Indicator Disease-Based Active Case Finding in a University Hospital: Results from the SHOT Project

open access: yesInfectious Disease Reports, 2023
In 2014, UNAIDS launched renewed global targets for HIV control to achieve by 2025, known as “the three 95”: 95% of people living with HIV (PWH) diagnosed, of which 95% are receiving treatment, of which 95% are on sustained virological suppression.
Andrea De Vito   +12 more
doaj   +1 more source

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