Results 91 to 100 of about 14,005,924 (265)

Perceptions of tuberculosis and home-based infection screening among families and providers in Madagascar: a qualitative study

BMC Public Health
Summary Background Madagascar is a country with a high tuberculosis (TB) burden, and the incidence of the disease has remained unchanged since 2013. TB detection largely relies on passive strategies, with little attention given to TB infections (TBIs ...
Voahirana Tantely Annick Andrianantoandro, Mamy Jean Jacques Razafimahatratra, Martine Audibert , Rila Ratovoson, Niaina Rakotosamimananan, Jonathan Hoffmann   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Importance of confirmatory test characteristics in optimizing community-based screening for tuberculosis: an epidemiological modeling analysis

BMC Infectious Diseases
Background The costs, operational barriers, and sensitivity of available tools to confirm a TB diagnosis limit current active case-finding (ACF) efforts for tuberculosis (TB).
Lukas E. Brümmer, Theresa S. Ryckman, Sourya Shrestha, Florian M. Marx, William Worodria, Devasahayam J. Christopher, Grant Theron, Adithya Cattamanchi, Claudia M. Denkinger, David W. Dowdy, Emily A. Kendall   +10 more
doaj   +1 more source

African American Scholars at Case

African American Scholars at Case is a digital initiative that focuses on the presence of African Americans at Case Western Reserve University since its inception.
Johnson, Gwendolyn G. (Creatorcre), Adeyemon, Earnestine (Creatorcre)   +1 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Chronic obstructive pulmonary disease – importance of active case finding and consideration of comorbidities

Swiss Medical Weekly, 2017
Frank Rassouli
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Application of Operations Research in Research Planning - A Case Study

Operations Research ...
Johnson, E. (Creatorcre)
core