Results 91 to 100 of about 790,871 (259)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Early detection of tuberculosis through community-based active case finding in Cambodia

, 2012
Background Since 2005, Cambodia’s national tuberculosis programme has been conducting active case finding (ACF) with mobile radiography units, targeting household contacts of TB patients in poor and vulnerable communities in addition to routine passive ...
Nishikiori Nobuyuki, van-Maaren Pieter, Satha Peou, Yadav Rajendra, Morishita Fukushi, Weezenbeek Catharina, Eang Mao   +6 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evaluation of a tuberculosis active case finding project in peri-urban areas, Myanmar: 2014-2016

, 2018
Objectives: We assessed the effect of an active case finding (ACF) project on tuberculosis (TB) case notification and the yields from a household and neigbourhood intervention (screening contacts of historical index TB patients diagnosed >24 months ago ...
S. Satyanarayana, Si Thu Aung, Suman S. Majumdar, Nang Thu Thu Kyaw, Khine Wut Yee Kyaw, Sandar Aye, Myo Minn Oo, Saw Thein, Nay Lynn Oo, Jaya Prasad Tripathy, Myat Kyaw Thu, Kyaw Thu Soe   +11 more
core   +1 more source

Factors associated with tuberculosis disease among children who are household contacts of tuberculosis cases in an urban setting in Malaysia

BMC Public Health, 2019
Background With the rise in prevalence of childhood tuberculosis (TB) globally, contact tracing should be a powerful strategy for early diagnosis and management, especially in children who are household contacts of active TB cases.
Noor Atika Azit, Aniza Ismail, Norfazilah Ahmad, Rohani Ismail, Shuhaily Ishak   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Usage of Mobile X-Rays in Active Case-Finding for Tuberculosis

Journal of Innovation and Community Engagement
Indonesia has the world’s second-highest number of tuberculosis cases. More than 300,000 cases of tuberculosis in Indonesia have not been diagnosed or recorded, which are known as the missing cases. Undiagnosed tuberculosis patients will cause the spread
Cindra Paskaria, Elizabeth Wianto, Hapnes Toba   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Analisis Pelaksanaan Strategi Passive Case Finding Dan Active Case Finding Dalam Penemuan Penderita TB Paru Di Wilayah Kerja Puskesmas Pangarengan Kecamatan Torjun Kabupaten Sampang [PDF]

Tuberculosis is the first disease category that cause death in Indonesia. Case of lung TB was incrasing in Indonesia. Two strategies of case finding lung TB, including passive case finding and active case finding.
Achmad Arodisi Afuani, -
core  

Cost-effectiveness of a tuberculosis active case finding program targeting household and neighborhood contacts in Cambodia.

, 2014
In many high-risk populations, access to tuberculosis (TB) diagnosis and treatment is limited and pockets of high prevalence persist. We estimated the cost-effectiveness of an extensive active case finding program in areas of Cambodia where TB ...
Nishikiori, N, Eang, MT, Lubell, Y, Yadav, RP, Satha, P, Lubell, Yoel   +5 more
core   +1 more source