Results 221 to 230 of about 4,534,827 (376)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference. [PDF]

Nat Commun
Hvorecny KL, Interlandi G, Veth TS, Aprikian P, Manchenko A, Tchesnokova VL, Dickinson MS, Quispe JD, Riley NM, Klevit RE, Magala P, Sokurenko EV, Kollman JM.   +12 more
europepmc   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Stress-Induced Reorganization of Proteasomes Through Diffusion and Cytoskeleton-Dependent Mechanisms. [PDF]

Small
Morten MJ, Zhang Y, Li B, Meng JX, Jiang K, Sirvio L, Lee JE, Lippert AH, Burridge M, Pulgar Prieto KD, Carr AR, Ponjavic A, Lee SF, Finley D, Klenerman D, Ye Y.   +15 more
europepmc   +1 more source

An Active Clamp Dual-Inductor Isolated Current Source to Current Source Converter with Wide Output Voltage Range [PDF]

Tiesheng Yan, Wenyuan Chen, Yu Zhou, Lin Dong, Jun Tian, Guohua Zhou   +5 more
openalex   +1 more source

Contributions to the design and operation of a multilevel-active-clamped Dc-Ac grid- connected power converter for wind energy conversion systems [PDF]

, 2017
Luis Caballero Diaz
openalex   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase. [PDF]

Nat Commun
Brewer J, Delbeau M, Zoullas WB, Darst SA, Campbell EA.   +4 more
europepmc   +1 more source

Simultaneous patch-clamp recording and calcium imaging in a rhythmically active neuronal network in the brainstem slice preparation from mouse

, 2000
Thomas Ladewig, Bernhard U. Keller
openalex   +1 more source