Results 31 to 40 of about 3,292,953 (161)

HIV-1 Gag Non-Cleavage Site PI Resistance Mutations Stabilize Protease/Gag Substrate Complexes In Silico via a Substrate-Clamp

BioChem, 2021
HIV-1 protease active site inhibitors are a key part of antiretroviral therapy, though resistance can evolve rendering therapy ineffective. Protease inhibitor resistance typically starts with primary mutations around the active site, which reduces ...
Gary S. Laco
doaj   +1 more source

Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes [PDF]

, 2012
Background and aim: Human atrial transient outward K+ current (ITO) is decreased in a variety of cardiac pathologies, but how ITO reduction alters action potentials (AP) and arrhythmia mechanisms is poorly understood, owing to non-selectivity of ITO ...
Marshall, G.E., Dempster, J., Smith, G.L., Rankin, A.C., Workman, A.J.   +4 more
core   +1 more source

Classical and numerical approaches to determining V-section band clamp axial stiffness [PDF]

, 2014
V-band clamp joints are used in a wide range of applications to connect circular flanges, for ducts, pipes and the turbocharger housing. Previous studies and research on V-bands are either purely empirical or analytical with limited applicability on the ...
Khodabakhshi, Goodarz, Barrans, Simon, Muller, Matthias, Khodabakhshi Goodarz, Barrans, Simon M., Muller Matthias, Barrans Simon M.   +6 more
core   +1 more source

Detailed Analysis of a Regenerative Active Clamping Snubber for a Phase-Shifted Converter

IEEE Access
The phase-shifted converter (PSFB) is one of the most used converters for applications where high power and galvanic isolation are required. To achieve zero voltage switching (ZVS) on the primary side these converters use the leakage inductance of the ...
Dorin Petreus, Toma Patarau
doaj   +1 more source

Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism

Frontiers in Pharmacology, 2023
Triterpenoid saponins from Stauntonia chinensis have been proven to be a potential candidate for inflammatory pain relief. Our pharmacological studies confirmed that the analgesic role of triterpenoid saponins from S.
Ji-Hong Gong, Chang-Ming Zhang, Bo Wu, Zi-Xun Zhang, Zhong-Yan Zhou, Jia-Hui Zhu, Han Liu, Yi Rong, Qian Yin, Ya-Ting Chen, Rong Zheng, Guang-Zhong Yang, Xiao-Fei Yang, Su Chen   +13 more
doaj   +1 more source

Active-Clamp Dual-Transformer ZVS Flyback Converter

Energies
In order to upgrade the ability of the traditional flyback converter to transfer energy to the load, a dual-flyback converter with two active clamping circuits is added, using the same clamping capacitor to recover the leakage inductance energy ...
Pei-Ching Tseng, Kuo-Ing Hwu, Yu-Lin Chen, Jenn-Jong Shieh   +3 more
doaj   +1 more source

Operculigera Clamp 1991

, 2003
Operculigera Clamp, 1991 Diagnosis. Solitary, loricate, with lorica aperture consisting of simple opening without either folded lips at its anterior and posterior edges or invaginated collar of lorica material (loricastome). Aperture closable by means
Kane, John R., Clamp, John C.
core   +1 more source

Performance comparison and analysis of quasi resonant and active clamp flyback converters

Dianzi Jishu Yingyong
High frequency, high efficiency, and high power density have become important design indicators for AC-DC converters. Traditional quasi resonant flyback converters, due to their reliance on passive resistive components to release leakage energy in the ...
Liu Zhibin, Pan Yongxiong, Wu Jianhong
doaj   +1 more source

Autism-associated mutations in the CaVβ2 calcium-channel subunit increase Ba2+-currents and lead to differential modulation by the RGK-protein Gem

Neurobiology of Disease, 2020
Voltage-gated calcium-channels (VGCCs) are heteromers consisting of several subunits. Mutations in the genes coding for VGCC subunits have been reported to be associated with autism spectrum disorder (ASD).
Patrick Despang, Sarah Salamon, Alexandra F. Breitenkamp, Elza Kuzmenkina, Stefan Herzig, Jan Matthes   +5 more
doaj   +1 more source

The Effects of Acute High‐Intensity Interval Exercise and Hyperinsulinemic‐Euglycemic Clamp on Osteoglycin Levels in Young and Middle‐Aged Men

JBMR Plus, 2022
Osteoglycin (OGN) is a leucine‐rich proteoglycan that has been implicated in the regulation of glucose in animal models. However, its relationship with glucose control in humans is unclear. We examined the effect of high‐intensity interval exercise (HIIE)
Carlie Bauer, Alexander Tacey, Andrew Garnham, Cassandra Smith, Mary N Woessner, Xuzhu Lin, Navabeh Zarekookandeh, David L Hare, Joshua R Lewis, Lewan Parker, Itamar Levinger   +10 more
doaj   +1 more source