Results 31 to 40 of about 82,647 (261)

HIV-1 Gag Non-Cleavage Site PI Resistance Mutations Stabilize Protease/Gag Substrate Complexes In Silico via a Substrate-Clamp

BioChem, 2021
HIV-1 protease active site inhibitors are a key part of antiretroviral therapy, though resistance can evolve rendering therapy ineffective. Protease inhibitor resistance typically starts with primary mutations around the active site, which reduces ...
Gary S. Laco
doaj   +1 more source

Phase Shift Full Bridge DC–DC Converter With Active Clamping Circuit for Fuel Cell Electric Vehicles

IEEE Access
This paper proposes a soft switching isolated phase-shifted full-bridge DC-DC converter using active clamping circuit for fuel cell power generation applications.
Bader N. Alajmi, Nabil A. Ahmed, Ibrahim Abdelsalam, Mostafa I. Marei   +3 more
doaj   +1 more source

Soft-Switching Technology of Three-Phase Six-Switch PFC Rectifier

Energies, 2020
An active clamp, three-phase, six-switch power factor correction rectifier with a one-cycle controller is proposed, which can effectively suppress the reverse recovery of the reverse parallel diode of the bridge arm switch and reduce the reverse recovery
Qihui Zhen, Qingyun Di
doaj   +1 more source

Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism

Frontiers in Pharmacology, 2023
Triterpenoid saponins from Stauntonia chinensis have been proven to be a potential candidate for inflammatory pain relief. Our pharmacological studies confirmed that the analgesic role of triterpenoid saponins from S.
Ji-Hong Gong, Chang-Ming Zhang, Bo Wu, Zi-Xun Zhang, Zhong-Yan Zhou, Jia-Hui Zhu, Han Liu, Yi Rong, Qian Yin, Ya-Ting Chen, Rong Zheng, Guang-Zhong Yang, Xiao-Fei Yang, Su Chen   +13 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Detailed Analysis of a Regenerative Active Clamping Snubber for a Phase-Shifted Converter

IEEE Access
The phase-shifted converter (PSFB) is one of the most used converters for applications where high power and galvanic isolation are required. To achieve zero voltage switching (ZVS) on the primary side these converters use the leakage inductance of the ...
Dorin Petreus, Toma Patarau
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

The Effects of Acute High‐Intensity Interval Exercise and Hyperinsulinemic‐Euglycemic Clamp on Osteoglycin Levels in Young and Middle‐Aged Men

JBMR Plus, 2022
Osteoglycin (OGN) is a leucine‐rich proteoglycan that has been implicated in the regulation of glucose in animal models. However, its relationship with glucose control in humans is unclear. We examined the effect of high‐intensity interval exercise (HIIE)
Carlie Bauer, Alexander Tacey, Andrew Garnham, Cassandra Smith, Mary N Woessner, Xuzhu Lin, Navabeh Zarekookandeh, David L Hare, Joshua R Lewis, Lewan Parker, Itamar Levinger   +10 more
doaj   +1 more source

Fatigue Crack Initiation and Growth in Nanocrystalline Ni at Multiple Length‐Scales

Advanced Engineering Materials, EarlyView.
Overview of miniaturized in situ SEM fatigue setup and resultant fatigue crack growth data for nanocrystalline Ni. The presented study focuses on the analysis of fatigue crack growth rate (FCGR) in focused ion beam‐notched microcantilevers prepared from nanocrystalline (NC) Ni as a model material.
Igor Moravcik, Alexander Jelinek, Markus Alfreider, Jutta Luksch, Anton Hohenwarter, Florian Schaefer, Christian Motz, Daniel Kiener   +7 more
wiley   +1 more source