Results 141 to 150 of about 75,070 (261)

Advanced automated classification and segmentation of leukemic cells using simulated optical scanning holography and active contour methods. [PDF]

J Biomed Opt
El-Ouarzadi A, Essadike A, Achaoui Y, Bouzid A.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Analyzing histopathological images using fused CNN features based on the geometric active contour method for early diagnosis of lung and colon cancer. [PDF]

Discov Oncol
Asiri Y, Senan EM, Halawani HT, Abunadi I, Mashraqi AM, Alshari EA.   +5 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

GLAC-Unet: Global-Local Active Contour Loss with an Efficient U-Shaped Architecture for Multiclass Medical Image Segmentation. [PDF]

J Imaging Inform Med
Trinh MN, Tran TT, Nham DH, Lo MT, Pham VT.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Breast tumor segmentation in ultrasound using distance-adapted fuzzy connectedness, convolutional neural network, and active contour. [PDF]

Sci Rep
Biesok M, Juszczyk J, Badura P.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Automatic 3D coronary artery segmentation based on local region active contour model. [PDF]

J Thorac Dis
Chen X, Jiang J, Zhang X.
europepmc   +1 more source

Ship Segmentation in SAR Images by Improved Nonlocal Active Contour Model. [PDF]

Sensors (Basel), 2018
Zhang X, Xiong B, Dong G, Kuang G.
europepmc   +1 more source